The significance of EMAP-II after allogeneic stem cell transplantation

Abstract Endothelial monocyte-activating polypeptide-II (EMAP-II) appears to play an important role in neovascularization and endothelial abnormalities. However, the role of EMAP-II in development of graft-versus-host disease (GVHD) after allogeneic SCT is poorly understood. We measured and compared...

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Bibliographic Details
Published in:Transplant immunology 2009-05, Vol.21 (1), p.23-26
Main Authors: Nomura, Shosaku, Ishii, Kazuyoshi, Shimizu, Michiomi, Inami, Norihito, Uoshima, Nobuhiko, Urase, Fumiaki, Maeda, Yasuhiro, Hayashi, Kunio
Format: Article
Language:English
Subjects:
Adult
Aged
Allergy and Immunology
Cytokines - metabolism
EMAP-II
Endothelial cell-derived microparticles
Female
Graft vs Host Disease - etiology
Graft vs Host Disease - immunology
Graft vs Host Disease - metabolism
GVHD
Humans
Male
Middle Aged
Neoplasm Proteins - metabolism
RNA-Binding Proteins - metabolism
Stem cell transplantation
Stem Cell Transplantation - adverse effects
Transplantation, Homologous
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Summary:Abstract Endothelial monocyte-activating polypeptide-II (EMAP-II) appears to play an important role in neovascularization and endothelial abnormalities. However, the role of EMAP-II in development of graft-versus-host disease (GVHD) after allogeneic SCT is poorly understood. We measured and compared the levels of EMAP-II, cytokines, and soluble factors in patients undergoing allogeneic SCT. The subjects were 23 patients who underwent allogeneic SCT. Most of the cytokines/soluble factors exhibited a significant elevation after allogeneic SCT, although Angiopoietin-1 did not change. On the other hand, the levels of these factors did not change significantly in the recipients of autologous SCT. When the relationship between EMAP-II and cytokines/soluble factors was analyzed, EMAP-II levels correlated positively with sIL-2R, sVCAM-1, sE-selectin, sFasL and EDMP. However, IL-6, Angiopoietin-1, Angiopoietin-2 and VEGF were not correlated with EMAP-II. Our results suggest that EMAP-II plays an important role in endothelial cell dysfunction related to GVHD after allogeneic SCT.
ISSN:0966-3274
1878-5492
DOI:10.1016/j.trim.2009.01.005