Beneficial effects of modern perfusion concepts in aortic valve and aortic root surgery

• Published in: Perfusion 2009-01, Vol.24 (1), p.37-44
• Main Authors: Kutschka, I, Skorpil, J, El Essawi, A, Hajek, T, Harringer, W
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aortic Valve - surgery; Blood Transfusion; C-Reactive Protein - analysis; Cardiopulmonary Bypass - instrumentation; Cardiopulmonary Bypass - methods; Coronary Artery Bypass - instrumentation; Coronary Artery Bypass - methods; Equipment Design; Female; Heart Valve Prosthesis Implantation - instrumentation; Heart Valve Prosthesis Implantation - methods; Humans; Length of Stay; Male; Middle Aged; ROC Curve
• ISSN: 0267-6591; 1477-111X
• DOI: 10.1177/0267659109106727

Minimized perfusion circuits (MPC) were found to reduce side effects of standard extracorporeal circulation (ECC). We evaluated the safety and efficacy of the ROCsafe™ MPC for aortic valve and aortic root surgery. One hundred and seventy patients were randomized for surgery using either MPC [n = 85, 30 female/55 male, mean age: 69.8 ± 11.8 years; aortic valve replacement (AVR): n = 40; AVR + coronary artery bypass graft (CABG): n = 31; David operation: n = 3; aortic root replacement (ARR): n = 11] or ECC [n = 85, 29 female/56 male, mean age: 67.7 ± 9.5 years; AVR: n = 39; AVR+CABG: n = 35, David operation: n = 2; ARR: n = 9]. Neurological status, length of ICU stay, C-reactive protein (CRP), blood count, transfusion requirements and bleeding volume were analyzed. The MPC system provided ultrasound-controlled de-airing. A small roller pump and a flexible reservoir were used for left ventricular venting. As a control, we used a standard ECC with cardiotomy suction and hard-shell reservoir. Cross-clamp time (MPC: 76.5 ± 29.5; ECC: 79.0 ± 34.0 min) and bypass time (MPC: 103.0 ± 37.9; ECC: 106.9 ± 44.9 min) were comparable between groups. Transfusion requirements (red blood cells: MPC: 1.5 ± 1.5 vs. ECC: 2.2 ± 2.1 units [p = 0.05], frozen plasma: MPC: 1.2 ± 1.8 vs. ECC: 1.9 ± 2.4 units [p = 0.03]), postoperative bleeding (MPC: 521 ± 283 vs. ECC: 615 ± 326 ml/24 h, p = 0.09) were lower using MPC. ICU stay was shorter with MPC (1.6 ± 1.6 days) compared to ECC (2.4 ± 2.8 days, p = 0.001). One stroke occurred in each group. The ROCsafe™ MPC provides safe circulatory support for a wide range of aortic valve surgeries. Transfusion requirements, postoperative bleeding and length of ICU stay were markedly reduced compared to standard extracorporeal perfusion.