Consecutive Intramolecular Hydroamination/Asymmetric Transfer Hydrogenation under Relay Catalysis of an Achiral Gold Complex/Chiral Brønsted Acid Binary System

Consecutive hydroamination/asymmetric transfer hydrogenation under relay catalysis of an achiral gold complex/chiral Brønsted acid binary system has been described for the direct transformation of 2-(2-propynyl)aniline derivatives into tetrahydroquinolines with high enantiomeric purity.

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Bibliographic Details
Published in:Journal of the American Chemical Society 2009-07, Vol.131 (26), p.9182-9183
Main Authors: Han, Zhi-Yong, Xiao, Han, Chen, Xiao-Hua, Gong, Liu-Zhu
Format: Article
Language:English
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Summary:Consecutive hydroamination/asymmetric transfer hydrogenation under relay catalysis of an achiral gold complex/chiral Brønsted acid binary system has been described for the direct transformation of 2-(2-propynyl)aniline derivatives into tetrahydroquinolines with high enantiomeric purity.
ISSN:0002-7863
1520-5126
DOI:10.1021/ja903547q