Human papillomavirus testing as a cytology gold standard: comparing Surinam with the Netherlands

Polymerase chain reaction to detect high-risk human papillomavirus has been suggested as a gold standard for cytology. The Netherlands and Surinam were prospectively compared in regard to the proportions of Negative, Atypical Squamous Cells of Undetermined Significance, and Squamous Intraepithelial...

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Bibliographic Details
Published in:Modern pathology 2005-03, Vol.18 (3), p.349-353
Main Authors: Wachtel, Mitchell S, Boon, Mathilde E, Korporaal, Hans, Kok, Lambrecht P
Format: Article
Language:English
Subjects:
Cervix Uteri - pathology
Cervix Uteri - virology
Cytodiagnosis - methods
Cytodiagnosis - standards
DNA, Viral - analysis
DNA, Viral - genetics
Female
human papillomavirus
Humans
Laboratory Medicine
Medicine
Medicine & Public Health
Netherlands
odds ratio
original-article
Papanicolaou Test
Papillomaviridae - genetics
Pathology
polymerase chain reaction
prevalence
Prospective Studies
Sensitivity and Specificity
squamous intraepithelial lesion
Suriname
Vaginal Smears - standards
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Summary:Polymerase chain reaction to detect high-risk human papillomavirus has been suggested as a gold standard for cytology. The Netherlands and Surinam were prospectively compared in regard to the proportions of Negative, Atypical Squamous Cells of Undetermined Significance, and Squamous Intraepithelial Lesion smears that had detectable high-risk human papillomavirus. For the Netherlands, 14 600 negative, 270 Atypical Squamous Cells of Undetermined Significance and 120 Squamous Intraepithelial Lesion smears were evaluated by polymerase chain reaction. For Surinam, 150 negative, 50 Atypical Squamous Cells of Undetermined Significance, and 150 Squamous Intraepithelial Lesion smears were evaluated by polymerase chain reaction. In all, 4% of Dutch and 80% of Surinamese negative smears had detectable high-risk human papillomavirus (χ2=1313, P
ISSN:0893-3952
1530-0285
DOI:10.1038/modpathol.3800242