New mechanisms for PRLr action in breast cancer

Prolactin (PRL) is a pleiotrophic hormone that contributes to the growth of normal and malignant breast tissues. PRL signals through its receptor (PRLr), a transmembrane receptor that belongs to the cytokine receptor family. The mechanism of how the PRL:PRLr interaction triggers activation of signal...

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Bibliographic Details
Published in:Trends in endocrinology and metabolism 2009-07, Vol.20 (5), p.223-229
Main Authors: Clevenger, Charles V, Gadd, Samantha L, Zheng, Jiamao
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Breast Neoplasms - metabolism
Cyclophilin A - pharmacology
Endocrinology & Metabolism
Female
Fundamental and applied biological sciences. Psychology
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
Medical sciences
Models, Biological
Prolactin - metabolism
Prolactin - physiology
Protein Multimerization
Receptors, Prolactin - metabolism
Signal Transduction - drug effects
Tumors
Vertebrates: endocrinology
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Summary:Prolactin (PRL) is a pleiotrophic hormone that contributes to the growth of normal and malignant breast tissues. PRL signals through its receptor (PRLr), a transmembrane receptor that belongs to the cytokine receptor family. The mechanism of how the PRL:PRLr interaction triggers activation of signaling networks remains enigmatic. This review examines the effect of ligand binding on PRLr and the processes that initiate receptor-associated signaling. Evidence for PRLr predimerization in the absence of ligand and the actions of the prolyl isomerase cyclophilin A in ligand-induced activation of PRLr-associated Jak2 kinase are discussed. These studies reveal that ligand-induced conformational change of the PRLr complex is necessary for its function and open avenues for therapies to inhibit PRLr action in breast cancer.
ISSN:1043-2760
1879-3061
DOI:10.1016/j.tem.2009.03.001