Attenuated prefrontal activation during a verbal fluency task in remitted major depression

The aim of the present study was to investigate whether a functional abnormality in the left prefrontal cortex observed in patients with major depression performing a verbal fluency task is present after remission of depression. Functional magnetic resonance imaging was used to study changes in cere...

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Bibliographic Details
Published in:Psychiatry and clinical neurosciences 2009-06, Vol.63 (3), p.423-425
Main Authors: Okada, Go, Okamoto, Yasumasa, Yamashita, Hidehisa, Ueda, Kazutaka, Takami, Hiroshi, Yamawaki, Shigeto
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
anterior cingulate cortex
Biological and medical sciences
Depression
Depressive Disorder, Major - drug therapy
Depressive Disorder, Major - metabolism
Depressive Disorder, Major - psychology
Female
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Mood disorders
prefrontal cortex
Prefrontal Cortex - metabolism
Psychology. Psychoanalysis. Psychiatry
Psychomotor Performance - physiology
Psychopathology. Psychiatry
remission
Verbal Behavior - physiology
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Summary:The aim of the present study was to investigate whether a functional abnormality in the left prefrontal cortex observed in patients with major depression performing a verbal fluency task is present after remission of depression. Functional magnetic resonance imaging was used to study changes in cerebral blood oxygenation in eight remitted patients with major depression and 10 healthy control subjects during a verbal fluency task. Compared to the control subjects, the patients had a reduced response in the left prefrontal cortex (middle frontal gyrus, Brodmann area 10). These findings suggest the presence of dysfunction in the left prefrontal cortex during remission in major depression.
ISSN:1323-1316
1440-1819
DOI:10.1111/j.1440-1819.2009.01952.x