Candida glabrata Endophthalmitis Treated Successfully with Caspofungin

A 39-year-old man with Candida glabrata endophthalmitis was successfully treated with a 28-day course of intravenous caspofungin. Presence of underlying renal insufficiency and infection with a drug-resistant strain precluded use of amphotericin B or fluconazole. Intravitreal administration of antif...

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Bibliographic Details
Published in:Clinical infectious diseases 2005-03, Vol.40 (5), p.e46-e48
Main Authors: Sarria, Juan C., Bradley, Jay C., Habash, Ranya, Mitchell, Kelly T., Kimbrough, Robert C., Vidal, Ana M.
Format: Article
Language:English
Subjects:
Adult
Antifungal Agents - therapeutic use
Candida glabrata
Candida glabrata - drug effects
Candida glabrata - isolation & purification
Candidiasis - diagnosis
Candidiasis - drug therapy
Candidiasis - microbiology
Drug Resistance, Multiple, Fungal
Echinocandins
Endophthalmitis - drug therapy
Endophthalmitis - microbiology
Endophthalmitis - pathology
Humans
Lipopeptides
Male
Peptides, Cyclic - therapeutic use
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Summary:A 39-year-old man with Candida glabrata endophthalmitis was successfully treated with a 28-day course of intravenous caspofungin. Presence of underlying renal insufficiency and infection with a drug-resistant strain precluded use of amphotericin B or fluconazole. Intravitreal administration of antifungals and vitrectomy were not required. The role of caspofungin in Candida endophthalmitis is discussed.
ISSN:1058-4838
1537-6591
DOI:10.1086/427753