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Predicting severity of cochlear hair cell damage in adult chickens using DPOAE input–output functions

Distortion product otoacoustic emissions (DPOAE) were recorded from the ear canal of aged broiler chickens which have been shown to present with age-related cochlear degeneration [Hear. Res. 166 (2002) 82]. We describe the relationship between the shape of the DPOAE input–output (I/O) function and t...

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Published in:Hearing research 2005-03, Vol.201 (1), p.109-120
Main Authors: Lichtenhan, Jeffery T., Chertoff, Mark E., Smittkamp, Susan E., Durham, Dianne, Girod, Douglas A.
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creator Lichtenhan, Jeffery T.
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description Distortion product otoacoustic emissions (DPOAE) were recorded from the ear canal of aged broiler chickens which have been shown to present with age-related cochlear degeneration [Hear. Res. 166 (2002) 82]. We describe the relationship between the shape of the DPOAE input–output (I/O) function and the type of hair cell damage present at and between the cochlear frequency places of the DPOAE primary tones ( f 1 and f 2). The mid stimulus level compressive growth of the mean DPOAE I/O functions is reduced in a graded fashion relative to the severity of hair cell damage. However, individual DPOAE I/O functions within most hair cell damage groups show large variability from this characteristic. Various least squares regression models were used to predict hair cell density from indices derived from the DPOAE I/O function (area, threshold and slope). The results showed that no simple linear relationship exists between hair cell density and the DPOAE I/O function indices. Multivariate binary logistic regression used DPOAE I/O function indices to predict membership in hair cell damage groups. The logistic model revealed that DPOAE threshold can be used to predict the occurrence of severe/total hair cell damage with good specificity though poor sensitivity.
doi_str_mv 10.1016/j.heares.2004.09.001
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subjects Aging - pathology
Aging - physiology
Analysis of Variance
Animals
Auditory
Avian
Binary logistic regression
Biological and medical sciences
Chickens
Distortion product otoacoustic emissions
Drug toxicity and drugs side effects treatment
Female
Hair Cells, Auditory - pathology
Hair Cells, Auditory - physiopathology
Hair Cells, Auditory - ultrastructure
Logistic Models
Medical sciences
Microscopy, Electron, Scanning
Observer Variation
Otoacoustic Emissions, Spontaneous - physiology
Pharmacology. Drug treatments
Presbycusis - pathology
Presbycusis - physiopathology
Severity of Illness Index
Toxicity: respiratory system, ent, stomatology
title Predicting severity of cochlear hair cell damage in adult chickens using DPOAE input–output functions
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