The Architecture of Protein-Ligand Binding Sites Revealed through Template-Assisted Intramolecular Peptide-Peptide Interactions

Matching Pairs: The interactions between template‐immobilized peptide pairs can provide a picture of ligand‐binding sites in proteins. If the members of a given peptide pair do not interact, a soluble protein can bind its ligand (picture, right). If the pair interacts, the peptide ligand is masked f...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2005-02, Vol.44 (9), p.1408-1412
Main Authors: Yu, Chao, Malesevic, Miroslav, Jahreis, Günther, Schutkowski, Mike, Fischer, Gunter, Schiene-Fischer, Cordelia
Format: Article
Language:English
Subjects:
Binding Sites
Blotting, Western
combinatorial chemistry
Combinatorial Chemistry Techniques - methods
conformational induction
Fluorenes - chemistry
Formic Acid Esters - chemistry
Ligands
Molecular Structure
Oligopeptides - chemistry
Oligopeptides - metabolism
peptides
Peptides - chemistry
Peptides - metabolism
Protein Array Analysis - methods
Protein Binding
Proteins - chemistry
Proteins - metabolism
spot synthesis
Streptavidin - chemistry
Streptavidin - metabolism
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Summary:Matching Pairs: The interactions between template‐immobilized peptide pairs can provide a picture of ligand‐binding sites in proteins. If the members of a given peptide pair do not interact, a soluble protein can bind its ligand (picture, right). If the pair interacts, the peptide ligand is masked from protein binding (left).
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200460991