Micropet imaging: in vivo biochemistry in small animals

Significant technological advancements required for imaging physiological function in small animals have been achieved in the last few years. Dedicated small animals PET scanners are now achieving resolutions that approach the one obtainable by autoradiographic methods, while still maintaining enoug...

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Bibliographic Details
Published in:Journal of Neural Transmission 2005-03, Vol.112 (3), p.319-330
Main Authors: Sossi, V, Ruth, T J
Format: Article
Language:English
Subjects:
Animals
Brain Chemistry - physiology
Disease Models, Animal
Humans
Mice
Positron-Emission Tomography - instrumentation
Positron-Emission Tomography - methods
Positron-Emission Tomography - trends
Positron-Emission Tomography - veterinary
Rats
Species Specificity
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Summary:Significant technological advancements required for imaging physiological function in small animals have been achieved in the last few years. Dedicated small animals PET scanners are now achieving resolutions that approach the one obtainable by autoradiographic methods, while still maintaining enough detection sensitivity to reliably measure biologically relevant parameters such as binding potentials or rate constants. Such developments have enabled researchers to explore in-vivo rodent models of human disease. The future in imaging now lies in the development of multi-modality imaging approaches, while the big challenge in the next few years will be for the chemists to develop tracers that are more specific and reflective of the functional condition under investigation, while miniaturizing the chemical synthesis related instrumentation.
ISSN:0300-9564
1435-1463
DOI:10.1007/s00702-004-0272-2