Intraclass correlation coefficient and outcome prevalence are associated in clustered binary data

• Published in: Journal of clinical epidemiology 2005-03, Vol.58 (3), p.246-251
• Main Authors: Gulliford, M.C., Adams, G., Ukoumunne, O.C., Latinovic, R., Chinn, S., Campbell, M.J.
• Format: Article
• Language: English
• Subjects: Binary data; Biological and medical sciences; Cardiovascular disease; Charitable foundations; Cluster randomization; Cluster sampling; Confidence intervals; Correlation coefficient; Data Interpretation, Statistical; Databases, Factual; Design; Diabetes; Epidemiology; Estimates; Family Practice; General aspects; Glucose; Health services; Health Services Research - methods; Humans; Intraclass correlation coefficient; Kappa; Medical sciences; Methodology; Prevalence; Primary Health Care; Public health. Hygiene; Public health. Hygiene-occupational medicine; Randomized Controlled Trials as Topic - methods; Research Design; Sample size; Studies; Technology assessment; Technology Assessment, Biomedical - methods; United Kingdom
• ISSN: 0895-4356; 1878-5921
• DOI: 10.1016/j.jclinepi.2004.08.012

To describe the association between values for a proportion and the intraclass correlation coefficient (ICC). Analysis of data obtained from the General Practice Research Database (GPRD) for variation between United Kingdom general practices and results from a Health Technology Assessment (HTA) review for a range of outcomes in community and health services settings. There were 188 ICCs from the GPRD, the median prevalence was 13.1% (interquartile range IQR 3.5 to 28.4%) and median ICC 0.051 (IQR 0.011 to 0.094). There were 136 ICCs from the HTA review, with median prevalence 6.5% (IQR 0.4 to 20.7%) and median ICC 0.006 (IQR 0.0003 to 0.036). There was a linear association of log ICC with log prevalence in both datasets (GPRD, regression coefficient 0.61, 95% confidence interval 0.53 to 0.69, P < 0.001; HTA, 0.91, 0.81 to 1.01, P < 0.001). When the prevalence was 1% the predicted ICC was 0.008 from the GPRD or 0.002 from the HTA, but when the prevalence was 40% the predicted ICC was 0.075 (GPRD) or 0.046 (HTA). The prevalence of an outcome may be used to make an informed assumption about the magnitude of the intraclass correlation coefficient.