A cohort study found that white blood cell count and endocrine markers predicted preterm birth in symptomatic women

This cohort study investigated potential clinical and biochemical predictors of subsequent preterm birth in women presenting with threatened preterm labor. Subjects were 218 pregnant women admitted to hospital with a diagnosis of threatened preterm labor at 22–36 weeks gestation. Exclusion criteria...

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Bibliographic Details
Published in:Journal of clinical epidemiology 2005-03, Vol.58 (3), p.304-310
Main Authors: Campbell, M. Karen, Challis, John R.G., DaSilva, Orlando, Bocking, Alan D.
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Adult
Biological and medical sciences
Biomarkers - blood
Cohort Studies
Corticotropin-releasing hormone
Corticotropin-Releasing Hormone - blood
Diseases of mother, fetus and pregnancy
Epidemiology
Female
Fetal Membranes, Premature Rupture - complications
Gestational Age
Gynecology. Andrology. Obstetrics
Humans
Leukocyte Count
Medical research
Medical sciences
Obstetric Labor, Premature - blood
Obstetric Labor, Premature - etiology
Obstetrics
Pregnancy
Pregnancy outcome
Pregnancy. Fetus. Placenta
Premature birth
Premature Birth - blood
Premature Birth - etiology
Prematurity
Preterm labor
Risk Factors
Studies
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Summary:This cohort study investigated potential clinical and biochemical predictors of subsequent preterm birth in women presenting with threatened preterm labor. Subjects were 218 pregnant women admitted to hospital with a diagnosis of threatened preterm labor at 22–36 weeks gestation. Exclusion criteria were multiple pregnancy, fetal anomalies, diabetes mellitus, abruptio placenta, preeclampsia, intrauterine growth restriction, cervical dilatation>4 cm, and clinical signs of infection. Analyses used logistic regression. The presence of ruptured membranes was the best predictor of birth within 48 hours. Other important predictors were maternal white blood cell count at 22–27 weeks gestation and maternal adrenocorticotropin and corticotropin-releasing hormone concentrations at 28–36 weeks gestation. Subclinical infection may be an important etiologic factor in preterm births of gestational age < 28 weeks. For those at ≥28 weeks gestation, the findings support the etiologic role of activation of the fetal and/or maternal hypothalamic pituitary adrenal axis leading to preterm birth.
ISSN:0895-4356
1878-5921
DOI:10.1016/j.jclinepi.2004.06.015