Role of Layer 6 of V2 Visual Cortex in Object-Recognition Memory

Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of V2 are crucial for the processing of object-recognition memory (ORM). Using the...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 2009-07, Vol.325 (5936), p.87-89
Main Authors: López-Aranda, Manuel F, López-Téllez, Juan F, Navarro-Lobato, Irene, Masmudi-Martín, Mariam, Gutiérrez, Antonia, Khan, Zafar U
Format: Article
Language:English
Subjects:
Animals
Brain
Cellular biology
Cerebral cortex
Cognition & reasoning
Eyes & eyesight
Hippocampus
Information processing
Lentivirus
Lentivirus - genetics
Memory
Memory - physiology
Memory, Short-Term - physiology
Neurons
Neurons - physiology
Rats
Rats, Wistar
Recognition (Psychology) - physiology
RGS Proteins - genetics
RGS Proteins - metabolism
Sensory perception
Temporal Lobe - physiology
Visual cortex
Visual Cortex - cytology
Visual Cortex - physiology
Visual memory
Visual Perception
Visual stimulation
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Summary:Cellular responses in the V2 secondary visual cortex to simple as well as complex visual stimuli have been well studied. However, the role of area V2 in visual memory remains unexplored. We found that layer 6 neurons of V2 are crucial for the processing of object-recognition memory (ORM). Using the protein regulator of G protein signaling-14 (RGS-14) as a tool, we found that the expression of this protein into layer 6 neurons of rat-brain area V2 promoted the conversion of a normal short-term ORM that normally lasts for 45 minutes into long-term memory detectable even after many months. Furthermore, elimination of the same-layer neurons by means of injection of a selective cytotoxin resulted in the complete loss of normal as well as protein-mediated enhanced ORM.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.1170869