BAFF and APRIL expression in B-cell chronic lymphocytic leukemia: Correlation with biological and clinical features

Abstract B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are involved in normal B cell survival and differentiation. We analyzed BAFF and APRIL plasma levels in patients with B-cell chronic lymphocytic leukemia (B-CLL). We also tested intracellular BAFF and APRIL expressi...

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Bibliographic Details
Published in:Leukemia research 2009-10, Vol.33 (10), p.1319-1327
Main Authors: Bojarska-Junak, Agnieszka, Hus, Iwona, Chocholska, Sylwia, Wąsik-Szczepanek, Ewa, Sieklucka, Małgorzata, Dmoszyńska, Anna, Roliński, Jacek
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
APRIL
B-Cell Activating Factor - blood
B-Cell Activating Factor - genetics
B-Cell Activating Factor - metabolism
B-CLL
B-Lymphocytes - pathology
BAFF
CD38
Female
Hematology, Oncology and Palliative Medicine
Humans
Leukemia, Lymphocytic, Chronic, B-Cell - blood
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - mortality
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Male
Middle Aged
Neoplasm Staging
Reverse Transcriptase Polymerase Chain Reaction
RNA, Neoplasm - genetics
Survival Analysis
Survivors
Tumor Necrosis Factor Ligand Superfamily Member 13 - blood
Tumor Necrosis Factor Ligand Superfamily Member 13 - genetics
Tumor Necrosis Factor Ligand Superfamily Member 13 - metabolism
ZAP-70
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Description
Summary:Abstract B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are involved in normal B cell survival and differentiation. We analyzed BAFF and APRIL plasma levels in patients with B-cell chronic lymphocytic leukemia (B-CLL). We also tested intracellular BAFF and APRIL expression in B-CLL and evaluated their prognostic relevance. The percentage of leukemic B cells with intracellular APRIL or BAFF expression correlated significantly with adverse prognostic factors such as ZAP-70 and CD38. Moreover, we found a close relationship between LPL protein expression or LPL/ADAM29 MFI ratio and proportion of B-CLL cells with intracellular BAFF or APRIL expression. Furthermore, patients with a low percentage of leukemic cells with intracellular BAFF or APRIL expression had a significantly longer overall survival than those with a high proportion of APRIL or BAFF positive leukemic cells.
ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2009.03.030