Impact of chimaerism analysis and kinetics on allogeneic haematopoietic stem cell transplantation outcome after conventional and reduced‐intensity conditioning regimens

Summary This retrospective study aimed to analyse the impact on overall survival (OS) and event‐free survival (EFS) of chimaerism status and kinetics following allogeneic conventional and reduced‐intensity conditioning haematopoietic stem cell transplantation, and to compare this with the impact of...

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Bibliographic Details
Published in:British journal of haematology 2005-03, Vol.128 (5), p.676-689
Main Authors: Michallet, Anne‐Sophie, Fürst, Sabine, Le, Quoc Hung, Dubois, Valérie, Praire, Aline, Nicolini, Franck, Thomas, Xavier, Rafii, Hanadi, Gebuhrer, Lucette, Michallet, Mauricette
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Disease-Free Survival
Female
Follow-Up Studies
full donor
Graft vs Host Disease
graft‐versus‐host disease
Hematologic and hematopoietic diseases
Hematologic Neoplasms - mortality
Hematologic Neoplasms - surgery
Hematology
Hematopoietic Stem Cell Transplantation - mortality
Humans
kinetics
Male
Medical sciences
Middle Aged
mixed chimaerism
Multivariate Analysis
Retrospective Studies
survival
Survival Analysis
Survival Rate
Transplantation Chimera
Transplantation Conditioning - methods
Transplantation, Homologous
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Summary:Summary This retrospective study aimed to analyse the impact on overall survival (OS) and event‐free survival (EFS) of chimaerism status and kinetics following allogeneic conventional and reduced‐intensity conditioning haematopoietic stem cell transplantation, and to compare this with the impact of other well‐known factors. We investigated the chimaerism status of 187 patients [84 females, 103 males; median age 39·5 years (range, 17–62 years)]. After transplantation, 121 patients (65%) presented full donor chimaerism (FDC) and 63 (34%) mixed chimaerism (MC). For MC, we divided the population into patients who presented regressive mixed chimaerism (RMC) (21 patients: 11%), stable mixed chimaerism (SMC) (20 patients: 11%) and progressive mixed chimaerism (PMC) (22 patients: 12%). At last follow‐up, 71 patients were alive and 116 had died (48% from disease progression and 52% from transplant‐related causes). With a mean follow‐up of 39·4 and 34·8 months, the 5‐year probabilities of OS and EFS for the total group were, respectively, 55% and 43%: 69·5% and 61% for FDC, 35·4% and 25% for RMC, 42·6% and 28·6% for SMC, and 21% and 10·4% for PMC (P 
ISSN:0007-1048
1365-2141
DOI:10.1111/j.1365-2141.2005.05372.x