nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7

Upon phylogenetic analysis of a partial S gene sequence [396 nucleotides (nt)], 928 hepatitis B virus (HBV) strains obtained from 899 viremic subjects in 28 major cities on 15 islands of Indonesia in 1989-2007 segregated into four HBV genotypes. Genotype B was predominant (66%), followed by genotype...

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Bibliographic Details
Published in:Archives of virology 2009-07, Vol.154 (7), p.1047-1059
Main Authors: Mulyanto, Depamede, Sulaiman Ngongu, Surayah, Kiely, Tsuda, Fumio, Ichiyama, Koji, Takahashi, Masaharu, Okamoto, Hiroaki
Format: Article
Language:English
Subjects:
Antibodies, Viral - blood
Bats
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Fundamental and applied biological sciences. Psychology
Genomes
Genotype
Genotype & phenotype
Geography
Hepatitis B
Hepatitis B - blood
Hepatitis B - epidemiology
Hepatitis B - genetics
Hepatitis B - immunology
Hepatitis B virus
Hepatitis B virus - classification
Hepatitis B virus - genetics
Hepatitis D - epidemiology
Hepatitis Delta Virus - genetics
Hepatitis Delta Virus - isolation & purification
Humans
Indonesia - epidemiology
Infections
Infectious Diseases
Islands
Medical Microbiology
Medicine
Microbiology
Minority & ethnic groups
Miscellaneous
Molecular Epidemiology - methods
Molecular Sequence Data
Original Article
Pacific Islands - epidemiology
Phylogenetics
Phylogeny
RNA, Viral - genetics
Virology
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Summary:Upon phylogenetic analysis of a partial S gene sequence [396 nucleotides (nt)], 928 hepatitis B virus (HBV) strains obtained from 899 viremic subjects in 28 major cities on 15 islands of Indonesia in 1989-2007 segregated into four HBV genotypes. Genotype B was predominant (66%), followed by genotype C (26%), genotype D (7%), and genotype A (0.8%). Comparative and phylogenetic analyses of the 396-nt S gene sequence of 928 HBV isolates and whole genomic sequences of 25 selected HBV isolates revealed a total of 14 subgenotypes within genotypes A-D: two (A1 and A2) in genotype A (HBV/A), five (B2, B3, B5, B7, and a novel subgenotype, tentatively designated B8) in HBV/B, five (C1, C2, C5, C6, and another novel subgenotype, C7) in HBV/C, and two (D1 and D3) in HBV/D. The distribution of HBV genotypes/subgenotypes, including B8 and C7, seems to be associated with ethnological origins in Indonesia.
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-009-0406-9