Multifarious proteomic signatures and regional heterogeneity in glioblastomas

To investigate the underlying intratumoral diversity of molecular profiles in glioblastomas, a proteomic approach was introduced to compare samples from regions of different histological grade. Using two-dimensional gel electrophoresis (2DE) with matrix-assisted laser-desorption/ionization time-of-f...

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Bibliographic Details
Published in:Journal of neuro-oncology 2009-08, Vol.94 (1), p.31-39
Main Authors: Park, Chul-Kee, Jung, Ji Hye, Park, Sung-Hye, Jung, Hee-Won, Cho, Byung-Kyu
Format: Article
Language:English
Subjects:
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
Electrophoresis, Gel, Two-Dimensional - methods
Glioblastoma - metabolism
Glioblastoma - pathology
Humans
Laboratory Investigation - Human/Animal Tissue
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Neoplasm Proteins - metabolism
Neurology
Oncology
Prealbumin - metabolism
Proteomics
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization - methods
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Summary:To investigate the underlying intratumoral diversity of molecular profiles in glioblastomas, a proteomic approach was introduced to compare samples from regions of different histological grade. Using two-dimensional gel electrophoresis (2DE) with matrix-assisted laser-desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS), we compared prospectively collected tissue samples of different histological grade areas of three glioblastoma patients. Consistent results showing relatively high expression of ubiquitin carboxyl-terminal esterase L1 in low-histological-grade areas (Grade 2 > Grades 3 and 4) and high expression of transthyretin in high-histological-grade areas (Grade 2 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-009-9805-8