Assessment of blood measures of n-3 polyunsaturated fatty acids with acute fish oil supplementation and washout in men and women

Abstract Changes in n-3 highly unsaturated fatty acids (HUFA, ≥20 carbons and ≥3 carbon–carbon double bonds) at baseline, during fish oil supplementation (4 weeks) and during washout (8 weeks) were compared in venous plasma, erythrocytes, whole blood and fingertip prick blood (weeks 0, 4, 8 and 12)...

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Published in:Prostaglandins, leukotrienes and essential fatty acids leukotrienes and essential fatty acids, 2009-07, Vol.81 (1), p.23-29
Main Authors: Metherel, A.H, Armstrong, J.M, Patterson, A.C, Stark, K.D
Format: Article
Language:English
Subjects:
Advanced Basic Science
Biological and medical sciences
Blood biomarker
Dietary Supplements
Docosahexaenoic acid
Eicosapentaenoic acid
Eicosapentaenoic Acid - blood
Endocrinology & Metabolism
Erythrocytes
Fatty Acids, Omega-3 - blood
Fatty Acids, Unsaturated - blood
Female
Fingertip prick blood
Fish Oils - administration & dosage
Fundamental and applied biological sciences. Psychology
Humans
Male
n-3 fatty acids
Plasma
Sex
Sex Factors
Supplementation
Vertebrates: endocrinology
Whole blood
Young Adult
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Summary:Abstract Changes in n-3 highly unsaturated fatty acids (HUFA, ≥20 carbons and ≥3 carbon–carbon double bonds) at baseline, during fish oil supplementation (4 weeks) and during washout (8 weeks) were compared in venous plasma, erythrocytes, whole blood and fingertip prick blood (weeks 0, 4, 8 and 12) with additional weekly fingertip prick samples. Correlations between the various blood fractions were slightly stronger when n-3 HUFA status was expressed as the percentage of n-3 HUFA in total HUFA as compared with the sum of EPA and DHA. Increases and decreases in n-3 HUFA were more dramatic in plasma, and EPA responded rapidly (within 1 week) with fish oil supplementation and cessation. Sex differences in the proportions of n-3 HUFA in blood were also apparent at baseline with females ( n =7) having a tendency for higher docosahexaenoic acid (DHA, 22:6n-3) relative to eicosapentaenoic acid (EPA, 20:5n-3) and n-3 docosapentaenoic acid (DPAn-3, 22:5n-3) as compared with males ( n =9). Further n-3 biomarker research in larger populations is required.
ISSN:0952-3278
1532-2823
DOI:10.1016/j.plefa.2009.05.018