Malettinins B−D:  New Polyketide Metabolites from an Unidentified Fungal Colonist of Hypoxylon Stromata (NRRL 29110)

Malettinins B−D (2−4), three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from nonsporulating cultures of an isolate of Mycelia sterilia MYC-155 (= NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2)...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2005-02, Vol.68 (2), p.212-216
Main Authors: Angawi, Rihab F, Swenson, Dale C, Gloer, James B, Wicklow, Donald. T
Format: Article
Language:English
Subjects:
Agaricales - chemistry
Agonomycetes
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents
Antifungal Agents - chemistry
Antifungal Agents - isolation & purification
Antifungal Agents - pharmacology
Applied microbiology
Bacillus subtilis - drug effects
Biological and medical sciences
Candida albicans - drug effects
chemical structure
Crystallography, X-Ray
decay fungi
Fundamental and applied biological sciences. Psychology
Furans - chemistry
Furans - isolation & purification
Furans - pharmacology
General aspects
Hypoxylon
malettinins
Microbiology
Molecular Structure
Mycelia sterilia
mycoparasites
New Mexico
Nuclear Magnetic Resonance, Biomolecular
polyketides
secondary metabolites
spectral analysis
Spiro Compounds - chemistry
Spiro Compounds - isolation & purification
Spiro Compounds - pharmacology
Staphylococcus aureus - drug effects
stereochemistry
tropolone
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Summary:Malettinins B−D (2−4), three new antimicrobial polyketide-derived metabolites related to the previously reported malettinin A (1), have been obtained from nonsporulating cultures of an isolate of Mycelia sterilia MYC-155 (= NRRL 29110) collected from colonies of Hypoxylon stromata. Malettinins B (2) and C (3) are partially reduced analogues of malettinin A and were identified by analysis of NMR and MS data. Malettinin D (4) is biogenetically similar, but possesses a new ring system, and the structure of 4 was established by single-crystal X-ray diffraction analysis.
ISSN:0163-3864
1520-6025
DOI:10.1021/np049625r