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The Association of Measured Breast Tissue Characteristics with Mammographic Density and Other Risk Factors for Breast Cancer

Background: We have examined the relationships between the measured properties of breast tissue and mammographic density and other risk factors for breast cancer, using breast tissue obtained at forensic autopsy and not selected for the presence of abnormalities. Methods: We used randomly selected t...

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Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 2005-02, Vol.14 (2), p.343-349
Main Authors: Li, Tong, Sun, Limei, Miller, Naomi, Nicklee, Trudey, Woo, Jennifer, Hulse-Smith, Lee, Tsao, Ming-Sound, Khokha, Rama, Martin, Lisa, Boyd, Norman
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cited_by cdi_FETCH-LOGICAL-c421t-264cb678b8f13603045f70a9a5748ee7b3e60fc89c8d3bb313b0d73599f0ebb13
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container_title Cancer epidemiology, biomarkers & prevention
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creator Li, Tong
Sun, Limei
Miller, Naomi
Nicklee, Trudey
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Khokha, Rama
Martin, Lisa
Boyd, Norman
description Background: We have examined the relationships between the measured properties of breast tissue and mammographic density and other risk factors for breast cancer, using breast tissue obtained at forensic autopsy and not selected for the presence of abnormalities. Methods: We used randomly selected tissue blocks taken from breast tissue slices obtained by s.c. mastectomy at the time of forensic autopsy to measure histologic features using quantitative microscopy. The proportions of the biopsy occupied by cells (estimated by nuclear area), glandular structures, and collagen were determined. These measurements were examined in relation to the percent density in the faxitron image of the tissue slice from which the biopsy was taken and other risk factors for breast cancer. Results: The percent mammographic density was associated with the proportion of the area of the biopsy occupied by nuclei, both epithelial and nonepithelial, and by collagen and the area of glandular structures. Several other risk factors for breast cancer, notably body weight, parity, and number of births, and menopausal status, that are associated with variations in mammographic density, were also associated with differences in one or more of these tissue features. Conclusion: All risk factors for breast cancer must ultimately exert their influence by an effect on the breast, and these findings suggest that, for some risk factors, this influence includes an effect on the number of cells and the quantity of collagen.
doi_str_mv 10.1158/1055-9965.EPI-04-0490
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Methods: We used randomly selected tissue blocks taken from breast tissue slices obtained by s.c. mastectomy at the time of forensic autopsy to measure histologic features using quantitative microscopy. The proportions of the biopsy occupied by cells (estimated by nuclear area), glandular structures, and collagen were determined. These measurements were examined in relation to the percent density in the faxitron image of the tissue slice from which the biopsy was taken and other risk factors for breast cancer. Results: The percent mammographic density was associated with the proportion of the area of the biopsy occupied by nuclei, both epithelial and nonepithelial, and by collagen and the area of glandular structures. Several other risk factors for breast cancer, notably body weight, parity, and number of births, and menopausal status, that are associated with variations in mammographic density, were also associated with differences in one or more of these tissue features. 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Obstetrics ; Humans ; Mammary gland diseases ; mammographic density ; Mammography ; Medical sciences ; Middle Aged ; Risk Factors ; Tumors</subject><ispartof>Cancer epidemiology, biomarkers &amp; prevention, 2005-02, Vol.14 (2), p.343-349</ispartof><rights>2005 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-264cb678b8f13603045f70a9a5748ee7b3e60fc89c8d3bb313b0d73599f0ebb13</citedby><cites>FETCH-LOGICAL-c421t-264cb678b8f13603045f70a9a5748ee7b3e60fc89c8d3bb313b0d73599f0ebb13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&amp;idt=16556325$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15734956$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Tong</creatorcontrib><creatorcontrib>Sun, Limei</creatorcontrib><creatorcontrib>Miller, Naomi</creatorcontrib><creatorcontrib>Nicklee, Trudey</creatorcontrib><creatorcontrib>Woo, Jennifer</creatorcontrib><creatorcontrib>Hulse-Smith, Lee</creatorcontrib><creatorcontrib>Tsao, Ming-Sound</creatorcontrib><creatorcontrib>Khokha, Rama</creatorcontrib><creatorcontrib>Martin, Lisa</creatorcontrib><creatorcontrib>Boyd, Norman</creatorcontrib><title>The Association of Measured Breast Tissue Characteristics with Mammographic Density and Other Risk Factors for Breast Cancer</title><title>Cancer epidemiology, biomarkers &amp; prevention</title><addtitle>Cancer Epidemiol Biomarkers Prev</addtitle><description>Background: We have examined the relationships between the measured properties of breast tissue and mammographic density and other risk factors for breast cancer, using breast tissue obtained at forensic autopsy and not selected for the presence of abnormalities. 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Methods: We used randomly selected tissue blocks taken from breast tissue slices obtained by s.c. mastectomy at the time of forensic autopsy to measure histologic features using quantitative microscopy. The proportions of the biopsy occupied by cells (estimated by nuclear area), glandular structures, and collagen were determined. These measurements were examined in relation to the percent density in the faxitron image of the tissue slice from which the biopsy was taken and other risk factors for breast cancer. Results: The percent mammographic density was associated with the proportion of the area of the biopsy occupied by nuclei, both epithelial and nonepithelial, and by collagen and the area of glandular structures. Several other risk factors for breast cancer, notably body weight, parity, and number of births, and menopausal status, that are associated with variations in mammographic density, were also associated with differences in one or more of these tissue features. 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identifier ISSN: 1055-9965
ispartof Cancer epidemiology, biomarkers & prevention, 2005-02, Vol.14 (2), p.343-349
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source Free E-Journal (出版社公開部分のみ)
subjects Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Breast - anatomy & histology
Breast - cytology
Breast - metabolism
Breast cancer
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - pathology
breast tissue
Cell Count
Collagen - metabolism
Female
Gynecology. Andrology. Obstetrics
Humans
Mammary gland diseases
mammographic density
Mammography
Medical sciences
Middle Aged
Risk Factors
Tumors
title The Association of Measured Breast Tissue Characteristics with Mammographic Density and Other Risk Factors for Breast Cancer
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