Association of gastrointestinal stromal tumor and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms h...

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Bibliographic Details
Published in:Tumori 2009-03, Vol.95 (2), p.240-242
Main Authors: Sonmez, Mehmet, Arslan, Mehmet, Cobanoglu, Umit, Kavgaci, Halil, Ozbas, Hasan Mucahit, Aydin, Fazil, Ovali, Ercument, Omay, Serdar Bedii
Format: Article
Language:English
Subjects:
Aged
Anemia, Refractory - etiology
Anemia, Refractory - pathology
Biopsy
Bone Marrow - pathology
Female
Gastrointestinal Stromal Tumors - complications
Gastrointestinal Stromal Tumors - pathology
Humans
Leukemia, Myeloid, Acute - complications
Leukemia, Myeloid, Acute - pathology
Myelodysplastic Syndromes - complications
Myelodysplastic Syndromes - pathology
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Summary:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. GISTs are believed to be related to mutational activation of receptor tyrosine kinases, KIT, or platelet-derived growth factor receptor-alpha. The coexistence of GISTs with other neoplasms has been extensively addressed in the literature. The most common second neoplasms are colorectal cancer, prostate cancer, and neoplasms derived from lymphoid tissue. In this case report, we describe a patient affected by GIST and acute myeloid leukemia preceded by myelodysplastic syndrome with refractory anemia. The clinicopathological characteristics of the patient are discussed and the literature is reviewed.
ISSN:0300-8916
2038-2529
DOI:10.1177/030089160909500218