The Halichondrins and E7389

The discovery and development of E7389 and halichondrins is discussed. The therapeutic applications of these compounds is explored.

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Bibliographic Details
Published in:Chemical reviews 2009-07, Vol.109 (7), p.3044-3079
Main Authors: Jackson, Katrina L, Henderson, James A, Phillips, Andrew J
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemical synthesis
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Biochemistry
Chemical compounds
Ethers, Cyclic - chemical synthesis
Ethers, Cyclic - chemistry
Ethers, Cyclic - pharmacology
Furans - chemical synthesis
Furans - chemistry
Furans - pharmacology
Humans
Ketones - chemical synthesis
Ketones - chemistry
Ketones - pharmacology
Macrolides
Medical research
Neoplasms - drug therapy
Pyrans - chemical synthesis
Pyrans - chemistry
Pyrans - pharmacology
R&D
Research & development
Structure-Activity Relationship
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Description
Summary:The discovery and development of E7389 and halichondrins is discussed. The therapeutic applications of these compounds is explored.
ISSN:0009-2665
1520-6890
DOI:10.1021/cr900016w