Hürthle (Oncocytic) Cell Tumors of Thyroid: Etiopathogenesis, Diagnosis and Clinical Significance

The etiopathogenesis and the classification of oncocytic (Hurthle cell) tumors of the thyroid is reviewed with an emphasis on the role played by mitochondrial and nuclear genetic abnormalities that interfere with mitochondrial function. Oxyphilia is classified into primary or secondary and the so-ca...

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Bibliographic Details
Published in:International journal of surgical pathology 2005-01, Vol.13 (1), p.29-35
Main Authors: Sobrinho-Simoes, Manuel, Maximo, Valdemar, de Castro, Ines Vieira, Fonseca, Elsa, Soares, Paula, Garcia-Rostan, Ginesa, de Oliveira, Manuel Cardoso
Format: Article
Language:English
Subjects:
Adenoma, Oxyphilic - classification
Adenoma, Oxyphilic - genetics
Adenoma, Oxyphilic - pathology
Cell Nucleus - genetics
Cell Nucleus - pathology
DNA, Mitochondrial
Humans
Mitochondria - genetics
Mitochondria - pathology
Thyroid Neoplasms - classification
Thyroid Neoplasms - genetics
Thyroid Neoplasms - pathology
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Summary:The etiopathogenesis and the classification of oncocytic (Hurthle cell) tumors of the thyroid is reviewed with an emphasis on the role played by mitochondrial and nuclear genetic abnormalities that interfere with mitochondrial function. Oxyphilia is classified into primary or secondary and the so-called Hurthle cell carcinoma is divided into oncocytic (Hurthle cell) variants of papillary and follicular carcinoma.
ISSN:1066-8969
1940-2465
DOI:10.1177/106689690501300104