Serious Antimicrobial Resistance Status of Pathogens Causing Hospital-acquired Lower Respiratory Tract Infections in North China

Antimicrobial resistance patterns of pathogens causing hospital-acquired lower respiratory tract infections (LRTIs) in Shandong Province, China were investigated using data collected from January 2002 to December 2006. A total of 10337 isolates were characterized in sputum samples from 39 920 LRTI p...

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Bibliographic Details
Published in:Journal of international medical research 2009-05, Vol.37 (3), p.899-907
Main Authors: Wang, Y, Zhang, R, Li, W, Feng, Y, Leng, T
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
China
Cross Infection - complications
Cross Infection - microbiology
Drug Resistance, Multiple, Bacterial - drug effects
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - isolation & purification
Humans
Microbial Sensitivity Tests
Respiratory Tract Infections - complications
Respiratory Tract Infections - microbiology
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Summary:Antimicrobial resistance patterns of pathogens causing hospital-acquired lower respiratory tract infections (LRTIs) in Shandong Province, China were investigated using data collected from January 2002 to December 2006. A total of 10337 isolates were characterized in sputum samples from 39 920 LRTI patients: 68.72% were Gram-negative bacteria, 20.65% were Gram-positive bacteria, and 10.62% were fungi. Organisms most frequently isolated were: Pseudomonas aeruginosa (16.88%), Klebsiella pneumoniae (10.80%), Escherichia coli (10.71%), fungi (10.62%), Staphylococcus aureus (9.68%) and Acinetobacter baumannii (9.03%). Imipenem was the most effective antibiotic against Gram-negative bacteria. Most Gram-positive bacteria were susceptible to vancomycin. Susceptibility to cephalosporins was not optimal and resistance to fluoroquinolones was high. Resistance of Gram-negative bacteria showed a rapid increase over the study period, while resistance of Gram-positive bacteria remained relatively stable. The emergence of resistance to commonly prescribed antimicrobial agents used against LRTI pathogens has compounded the problem of using empirical therapy and created selective pressure on physicians to use certain antibiotics.
ISSN:0300-0605
1473-2300
DOI:10.1177/147323000903700336