Copper(I)-Catalyzed Aryl Bromides To Form Intermolecular and Intramolecular Carbon−Oxygen Bonds

A highly efficient Cu-catalyzed C−O bond-forming reaction of alcohol and aryl bromides has been developed. This transformation was realized through the use of copper(I) iodide as a catalyst, 8-hydroxyquinoline as a ligand, and K3PO4 as a base. A variety of functionalized substrates were found to rea...

Full description

Saved in:
Bibliographic Details
Published in:Journal of organic chemistry 2009-07, Vol.74 (14), p.5075-5078
Main Authors: Niu, Jiajia, Guo, Pengran, Kang, Juntao, Li, Zhigang, Xu, Jingwei, Hu, Shaojing
Format: Article
Language:English
Subjects:
Bromides - chemistry
Carbon - chemistry
Catalysis
Catalysts: preparations and properties
Chemistry
Copper - chemistry
Exact sciences and technology
General and physical chemistry
Heterocyclic compounds
Heterocyclic compounds with only one n hetero atom and condensed derivatives
Ligands
Noncondensed benzenic compounds
Organic chemistry
Oxygen - chemistry
Oxyquinoline - chemistry
Phosphates - chemistry
Potassium Compounds - chemistry
Preparations and properties
Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A highly efficient Cu-catalyzed C−O bond-forming reaction of alcohol and aryl bromides has been developed. This transformation was realized through the use of copper(I) iodide as a catalyst, 8-hydroxyquinoline as a ligand, and K3PO4 as a base. A variety of functionalized substrates were found to react under these reaction conditions to provide products in good to excellent yields.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo900600m