Combined morphine and limb remote ischaemia postconditioning may produce an enhanced cardioprotection

Summary The limb remote ischaemia postconditioning (RIPOC), a newly conceived idea of applying brief limb ischaemic stimulus after onset of the myocardial ischaemia but prior to the reperfusion, can offer the possibility of applying this cardioprotective strategy to the patients with acute myocardia...

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Bibliographic Details
Published in:Medical hypotheses 2009-09, Vol.73 (3), p.302-305
Main Authors: Xu, Y.C, Xue, F.S, Liao, X, Xiong, J, Yang, Q.Y, Wang, W.L, Zhang, Y.M
Format: Article
Language:English
Subjects:
Cardiotonic Agents - administration & dosage
Combined Modality Therapy
Extremities - blood supply
Humans
Internal Medicine
Ischemic Preconditioning - methods
Models, Cardiovascular
Morphine - administration & dosage
Myocardial Infarction - physiopathology
Myocardial Infarction - prevention & control
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Summary:Summary The limb remote ischaemia postconditioning (RIPOC), a newly conceived idea of applying brief limb ischaemic stimulus after onset of the myocardial ischaemia but prior to the reperfusion, can offer the possibility of applying this cardioprotective strategy to the patients with acute myocardial infraction. Although increasing numbers of circles and duration of limb ischaemia may augment the protective effect of the limb RIPOC, these ways are not feasible in a clinical setting. Morphine, a classic opioid drug, has been proven to enhance the cardioprotection obtained by the other interventions. Because both the RPIOC and opioid drugs produce the cardioprotection by multiple pathways, and there may be overlaps and cross talk in their mechanisms, we hypothesize that a combination of morphine and the limb RIPOC may produce an enhanced cardioprotection.
ISSN:0306-9877
1532-2777
DOI:10.1016/j.mehy.2009.04.004