Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage

• Published in: Thrombosis research 2005, Vol.115 (5), p.367-373
• Main Authors: Saloheimo, Pertti, Juvela, Seppo, Riutta, Asko, Pyhtinen, Juhani, Hillbom, Matti
• Format: Article
• Language: English
• Subjects: 6-Ketoprostaglandin F1 alpha - analogs & derivatives; 6-Ketoprostaglandin F1 alpha - urine; Acute Disease; Aged; Aspirin; Aspirin - pharmacology; Biological and medical sciences; Bleeding Time; Blood and lymphatic vessels; Blood Coagulation - drug effects; Cardiology. Vascular system; Cerebral hemorrhage; Cerebral Hemorrhage - blood; Cerebral Hemorrhage - metabolism; Cerebral Hemorrhage - urine; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Epoprostenol - biosynthesis; Female; Hemostasis; Humans; Male; Medical sciences; Middle Aged; Neurology; Platelets; Prospective Studies; Prostacyclin; Regression Analysis; Thromboxane; Thromboxane A2 - biosynthesis; Thromboxane B2 - analogs & derivatives; Thromboxane B2 - urine; Vascular diseases and vascular malformations of the nervous system
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2004.08.026

Objective: Elevated levels of 11-dehydrothromboxane B 2 (11-dehydro-TXB 2) excreted in urine have been observed in acute ischemic stroke. This marker of platelet activation has not been investigated in patients with acute spontaneous intracerebral hemorrhage (ICH). Methods: We examined 43 patients with spontaneous ICH and 23 controls. Urinary excretion rates of 11-dehydro-TXB 2, 2,3-dinor-thromboxane B 2 (2,3 dinor-TXB 2) and 2,3-dinor-6-ketoprostaglandin F 1α (2,3-dinor-PGF 1α) during the first week and at 3 months after ICH were compared between patients who had or had not used aspirin and controls. Results: On admission, ICH patients without aspirin use had significantly higher urinary levels of 11-dehydro-TXB 2 ( p