TNF-alpha -308G/A and IL-6 -174 G/C polymorphisms in the Turkish pediatric stroke patients

Introduction: Stroke is an important cause of mortality and morbidity in the pediatric age group. There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke. These proinflammat...

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Bibliographic Details
Published in:Thrombosis research 2005, Vol.115 (5), p.393-398
Main Authors: Karahan, Zeynep Ceren, Deda, Gülhis, Sipahi, Tansu, Elhan, Atilla H, Akar, Nejat
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Child
Child, Preschool
DNA Restriction Enzymes - chemistry
Female
Gene Frequency
Genotype
Humans
Infant
Infant, Newborn
Interleukin-6 - blood
Interleukin-6 - genetics
Interleukin-6 - metabolism
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Risk Factors
Stroke - blood
Stroke - epidemiology
Stroke - genetics
Transcription, Genetic
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
Turkey - epidemiology
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Summary:Introduction: Stroke is an important cause of mortality and morbidity in the pediatric age group. There is increasing evidence on the role of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) in the occurrence and outcome of stroke. These proinflammatory cytokines carry functional polymorphisms (IL-6 -174 G/C and TNF-alpha -308 G/A) in their promoter regions, affecting their transcription rate and plasma cytokine levels. The aim of this study was to investigate the association of these polymorphisms with the occurrence of stroke in the Turkish pediatric stroke patients. Eighty six arterial stroke patients (aged between 0 and 14) and 83 healthy unrelated adult controls without personal or family history of stroke were investigated by PCR and restriction endonuclease analysis for IL-6 -174 G/C and TNF-alpha -308 G/A polymorphisms. The allele distribution, allele frequencies, and combined distribution of genotypes for both polymorphisms did not differ significantly between control and patient groups. The two polymorphisms did not associate with the occurrence of stroke in our study group.
ISSN:0049-3848
DOI:10.1016/j.thromres.2004.09.008