Usefulness of chemotherapy associated with surgery in the management of nontuberculous mycobacterial adenitis

In recent years, lymphadenitis caused by atypical mycobacteria (also called nontuberculous mycobacteria [NTMB] or, more recently, environmental) have played a significant role in the differential diagnosis of adenitis in non-immunocompromised children. To describe the clinical and pathological findi...

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Bibliographic Details
Published in:Anales de pediatría (Barcelona, Spain : 2003) Spain : 2003), 2005-03, Vol.62 (3), p.280-285
Main Authors: Sanz Santaeufemia, F J, Ramos Amador, J T, Giangaspro, E, Sánchez Granados, J M, Palenque, E, González Tomé, M I
Format: Article
Language:Spanish
Subjects:
Child, Preschool
Ciprofloxacin - therapeutic use
Clarithromycin - therapeutic use
Combined Modality Therapy
Drug Therapy, Combination - therapeutic use
Female
Humans
Infant
Lymphadenitis - drug therapy
Lymphadenitis - microbiology
Lymphadenitis - surgery
Male
Mycobacterium Infections, Nontuberculous - diagnosis
Mycobacterium Infections, Nontuberculous - drug therapy
Mycobacterium Infections, Nontuberculous - surgery
Retrospective Studies
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Summary:In recent years, lymphadenitis caused by atypical mycobacteria (also called nontuberculous mycobacteria [NTMB] or, more recently, environmental) have played a significant role in the differential diagnosis of adenitis in non-immunocompromised children. To describe the clinical and pathological findings in childhood NTMB adenitis and study the possible usefulness of antimicrobial therapy in addition to surgery. We present eight cases of neck lymphadenitis occurring over a 5-year period. All of the children received combined chemotherapy, and six also underwent surgery. Of the two remaining patients, the parents of one child refused surgery and a watchful approach was adopted in the other. Complete clinical recovery was achieved in all patients except one who did not undergo surgery. Prolonged administration of two antibiotics (of which one must be clarithromycin) in addition to surgery was well-tolerated and could be useful in patients with NTMB neck lymphadenitis.
ISSN:1695-4033