Diagnostic, Prognostic, and Therapeutic Implications of Genetic Testing for Hypertrophic Cardiomyopathy

Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting approximately 1 in 500 individuals, HCM is the most common cause of sudden death in young athletes. In recent years, gen...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the American College of Cardiology 2009-07, Vol.54 (3), p.201-211
Main Authors: Bos, J. Martijn, MD, Towbin, Jeffrey A., MD, Ackerman, Michael J., MD, PhD
Format: Article
Language:English
Subjects:
Cardiology
Cardiomyopathy
Cardiomyopathy, Hypertrophic - diagnosis
Cardiomyopathy, Hypertrophic - drug therapy
Cardiomyopathy, Hypertrophic - genetics
Cardiovascular
Disease
Echocardiography
Gene expression
Genetic Predisposition to Disease
Genetic Testing
Genomics
Humans
hypertrophic
Internal Medicine
Kinases
Muscular system
Mutation
Pathogenesis
Pharmacogenetics
Prognosis
Proteins
Rodents
Signal transduction
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Over the last 2 decades, the pathogenic basis for the most common heritable cardiovascular disease, hypertrophic cardiomyopathy (HCM), has been investigated extensively. Affecting approximately 1 in 500 individuals, HCM is the most common cause of sudden death in young athletes. In recent years, genomic medicine has been moving from the bench to the bedside throughout all medical disciplines including cardiology. Now, genomic medicine has entered clinical practice as it pertains to the evaluation and management of patients with HCM. The continuous research and discoveries of new HCM susceptibility genes, the growing amount of data from genotype-phenotype correlation studies, and the introduction of commercially available genetic tests for HCM make it essential that the modern-day cardiologist understand the diagnostic, prognostic, and therapeutic implications of HCM genetic testing.
ISSN:0735-1097
1558-3597
DOI:10.1016/j.jacc.2009.02.075