Maintenance of gene expression patterns

In development, cells pass on established gene expression patterns to daughter cells over multiple rounds of cell division. The cellular memory of the gene expression state is termed maintenance, and the proteins required for this process are termed maintenance proteins. The best characterized are p...

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Bibliographic Details
Published in:Developmental dynamics 2005-03, Vol.232 (3), p.633-655
Main Authors: Brock, Hugh W., Fisher, Cynthia L.
Format: Article
Language:English
Subjects:
Animals
DNA - biosynthesis
DNA-Binding Proteins - genetics
enhancer of trithorax and polycomb
Epigenesis, Genetic
epigenetics
Gene Expression
Gene Expression Regulation, Developmental
Gene Silencing
Genes, Homeobox
histone methylation
Homeodomain Proteins - biosynthesis
Homeodomain Proteins - chemistry
Homeodomain Proteins - genetics
Hox gene regulation
Humans
maintenance elements
maintenance proteins
Models, Genetic
Polycomb
Protein Structure, Tertiary
Transcription Factors - biosynthesis
Transcription Factors - genetics
trithorax
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Summary:In development, cells pass on established gene expression patterns to daughter cells over multiple rounds of cell division. The cellular memory of the gene expression state is termed maintenance, and the proteins required for this process are termed maintenance proteins. The best characterized are proteins of the Polycomb and trithorax Groups that are required for silencing and maintenance of activation of target loci, respectively. These proteins act through DNA elements termed maintenance elements. Here, we re‐examine the genetics and molecular biology of maintenance proteins. We discuss molecular models for the maintenance of activation and silencing, and the establishment of epigenetic marks, and suggest that maintenance proteins may play a role in propagating the mark through DNA synthesis. Developmental Dynamics 232:633–655, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1058-8388
1097-0177
DOI:10.1002/dvdy.20298