Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting

• Published in: Stroke (1970) 2005-03, Vol.36 (3), p.676-678
• Main Authors: KO, Nerissa U, ACHROL, Achal S, MARTIN, Alastair J, CHOPRA, Manju, SALONER, David A, HIGASHIDA, Randall T, YOUNG, William L
• Format: Article
• Language: English
• Subjects: Aged; Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood Flow Velocity - physiology; Cardiology. Vascular system; Carotid Stenosis; Cerebrovascular Circulation; Hemodynamics - physiology; Humans; Image Processing, Computer-Assisted - methods; Investigative techniques, diagnostic techniques (general aspects); Magnetic Resonance Angiography - methods; Magnetic Resonance Spectroscopy - methods; Medical sciences; Nervous system; Neurology; Radiodiagnosis. Nmr imagery. Nmr spectrometry; Stents; Vascular diseases and vascular malformations of the nervous system; Xenon Radioisotopes - analysis
• ISSN: 0039-2499; 1524-4628
• DOI: 10.1161/01.STR.0000155743.60019.e5

To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial (133)Xe washout method. Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial (133)Xe washout before and after carotid stenting. MR perfusion was compared with 133Xe-CBF values using Pearson linear correlation analysis. We observed a mean 37+/-38% increase in 133Xe-CBF and a mean 19+/-27% increase in relative CBF (rCBF) by MR perfusion immediately after stent placement. Relative (percent) changes in MR-rCBF showed a close and linear correlation to those seen in 133Xe-CBF (r=0.91; R2=0.84; P=0.002). There was a trend for MR perfusion to underestimate change in CBF at higher relative changes in flow. Bolus-tracking MR perfusion correlates with 133Xe-CBF in estimating postprocedural increases in blood flow but may underestimate the magnitude of the change with higher relative changes.