Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting

To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial (133)Xe washout method. Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial (133)Xe washout before and after carotid stenting. MR...

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Published in:Stroke (1970) 2005-03, Vol.36 (3), p.676-678
Main Authors: KO, Nerissa U, ACHROL, Achal S, MARTIN, Alastair J, CHOPRA, Manju, SALONER, David A, HIGASHIDA, Randall T, YOUNG, William L
Format: Article
Language:English
Subjects:
Aged
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity - physiology
Cardiology. Vascular system
Carotid Stenosis
Cerebrovascular Circulation
Hemodynamics - physiology
Humans
Image Processing, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Angiography - methods
Magnetic Resonance Spectroscopy - methods
Medical sciences
Nervous system
Neurology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Stents
Vascular diseases and vascular malformations of the nervous system
Xenon Radioisotopes - analysis
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container_end_page 678
container_issue 3
container_start_page 676
container_title Stroke (1970)
container_volume 36
creator KO, Nerissa U
ACHROL, Achal S
MARTIN, Alastair J
CHOPRA, Manju
SALONER, David A
HIGASHIDA, Randall T
YOUNG, William L
description To compare magnetic resonance (MR) perfusion to gold-standard cerebral blood flow (CBF) determined by intra-arterial (133)Xe washout method. Eight patients with high-grade carotid stenoses underwent bolus-tracking MR perfusion and intra-arterial (133)Xe washout before and after carotid stenting. MR perfusion was compared with 133Xe-CBF values using Pearson linear correlation analysis. We observed a mean 37+/-38% increase in 133Xe-CBF and a mean 19+/-27% increase in relative CBF (rCBF) by MR perfusion immediately after stent placement. Relative (percent) changes in MR-rCBF showed a close and linear correlation to those seen in 133Xe-CBF (r=0.91; R2=0.84; P=0.002). There was a trend for MR perfusion to underestimate change in CBF at higher relative changes in flow. Bolus-tracking MR perfusion correlates with 133Xe-CBF in estimating postprocedural increases in blood flow but may underestimate the magnitude of the change with higher relative changes.
doi_str_mv 10.1161/01.STR.0000155743.60019.e5
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source Alma/SFX Local Collection
subjects Aged
Atherosclerosis (general aspects, experimental research)
Biological and medical sciences
Blood and lymphatic vessels
Blood Flow Velocity - physiology
Cardiology. Vascular system
Carotid Stenosis
Cerebrovascular Circulation
Hemodynamics - physiology
Humans
Image Processing, Computer-Assisted - methods
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Angiography - methods
Magnetic Resonance Spectroscopy - methods
Medical sciences
Nervous system
Neurology
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Stents
Vascular diseases and vascular malformations of the nervous system
Xenon Radioisotopes - analysis
title Magnetic resonance perfusion tracks 133Xe cerebral blood flow changes after carotid stenting
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