Araloside A, an Antiulcer Constituent from the Root Bark of Aralia elata

Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at ora...

Full description

Saved in:
Bibliographic Details
Published in:Biological & Pharmaceutical Bulletin 2005, Vol.28(3), pp.523-526
Main Authors: Lee, Eun Bang, Kim, Oon Ja, Kang, Sam Sik, Jeong, Choonsik
Format: Article
Language:English
Subjects:
Animals
Anti-Ulcer Agents - isolation & purification
Anti-Ulcer Agents - therapeutic use
antiulcer activity
Aralia
Aralia elata
Araliaceae
araloside A
Male
Oleanolic Acid - analogs & derivatives
Oleanolic Acid - isolation & purification
Oleanolic Acid - therapeutic use
Plant Bark
Plant Extracts - isolation & purification
Plant Extracts - therapeutic use
Plant Roots
Rats
Rats, Sprague-Dawley
Saponins - isolation & purification
Saponins - therapeutic use
Stomach Ulcer - drug therapy
Stomach Ulcer - pathology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Araloside A, a potent inhibitor of gastric lesion and ulcer formation in rats, was isolated from the root bark of Aralia elata through a bioassay-guided separation procedure. The compound exhibited significant reduction of HCl·ethanol-induced gastric lesions and aspirin-induced gastric ulcers at oral doses of 50 and 100 mg/kg, respectively. These activities are comparable to those of cimetidine.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.523