Salbutamol pMDI gives less protection to methacholine induced airway obstruction than salbutamol via spacer or DPI

Inhalation device and inhalation technique influence the deposition of drug in the lung. This study evaluated the efficacy of salbutamol as a bronchoprotective agent administered via Diskus, Turbuhaler, pMDI or pMDI + Volumatic against methacholine-induced bronchoconstriction. Twenty stable asthmati...

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Bibliographic Details
Published in:European journal of clinical pharmacology 2005-02, Vol.60 (12), p.837-841
Main Authors: BROEDERS, Mariëlle E. A. C, MOLEMA, Johan, HOP, Wim C. J, FOLGERING, Hans T. M
Format: Article
Language:English
Subjects:
Administration, Inhalation
Albuterol - administration & dosage
Albuterol - therapeutic use
Asthma - drug therapy
Biological and medical sciences
Bronchial Provocation Tests
Bronchoconstrictor Agents
Bronchodilator Agents - administration & dosage
Bronchodilator Agents - therapeutic use
Female
Humans
Male
Medical sciences
Metered Dose Inhalers
Methacholine Chloride
Middle Aged
Nebulizers and Vaporizers
Pharmacology. Drug treatments
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Summary:Inhalation device and inhalation technique influence the deposition of drug in the lung. This study evaluated the efficacy of salbutamol as a bronchoprotective agent administered via Diskus, Turbuhaler, pMDI or pMDI + Volumatic against methacholine-induced bronchoconstriction. Twenty stable asthmatics participated in this open randomised comparison of the protective effects of 200 microg salbutamol, administered via the various inhalation devices on methacholine-induced airway obstruction, with respect to pulmonary function and dyspnoea sensation. The inhalation technique was controlled by measuring the peak inspiratory flow (and actuation time, in the case of pMDI and Volumatic) through the device, during inhalation. Inhalation of salbutamol increased the provocative dose of methacholine by 1.2 doubling doses (dd) for pMDI, 1.9 dd for Diskus, 2.3 dd for Turbuhaler and 2.5 dd for Volumatic. Salbutamol via pMDI provided less protection from methacholine-induced airway obstruction than did salbutamol administered via Diskus, Turbuhaler or Volumatic (P
ISSN:0031-6970
1432-1041
DOI:10.1007/s00228-004-0844-y