Limitations of glomerular filtration rate equations in the renal transplant patient

:  This study aims to compare the performance of endogenous creatinine clearance (CLcr) and a number of published mathematical equations to calculate glomerular filtration rate (GFR) in renal transplant patients considering 99mTc DTPA isotope scan as the reference method. A total of 152 GFR were per...

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Bibliographic Details
Published in:Clinical transplantation 2005-04, Vol.19 (2), p.259-268
Main Authors: Raju, Dharmapaul L, Grover, Vaneeta K, Shoker, Ahmed
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Bias
Biological and medical sciences
Body Mass Index
Cardiology. Vascular system
Creatinine - blood
Creatinine - urine
creatinine clearance equations
Female
Forecasting
glomerular filtration rate
Glomerular Filtration Rate - physiology
Humans
Kidney - diagnostic imaging
Kidney - metabolism
Kidney Transplantation - physiology
Male
Mathematics
Medical sciences
Middle Aged
Models, Biological
Nephrology. Urinary tract diseases
Radionuclide Imaging
Radiopharmaceuticals
renal transplant
Retrospective Studies
Technetium Tc 99m Pentetate
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Summary::  This study aims to compare the performance of endogenous creatinine clearance (CLcr) and a number of published mathematical equations to calculate glomerular filtration rate (GFR) in renal transplant patients considering 99mTc DTPA isotope scan as the reference method. A total of 152 GFR were performed on 81 renal transplant patients. Accuracy of each method was measured at different percentiles. The bias and precision of all the methods were then compared. A paired t‐test was used to compare the performance of each calculation to the respective GFR measured by isotope study performed on the same day. In the total population, all calculated methods correlated significantly with the isotope results. Accuracies within specific ranges of the isotope GFR were limited in all equations (agreement with isotope result ≤72% at 30% accuracy range in the total group). Within the limited accuracy, Edwards’ equation (K.D. Edwards and H.M. Whyte, Australas Ann Med 1959; vol. 8: p. 218) had the least bias in the total population. Bjornsson (T.D. Bjornsson, Clin Pharmacokinet 1979; vol. 4: p. 200) had the least bias in patients with GFR ≥ 50 mL/min and Gates in patients with GFR 
ISSN:0902-0063
1399-0012
DOI:10.1111/j.1399-0012.2005.00335.x