Prevalence of a Tertiary Gleason Grade and Its Impact on Adverse Histopathologic Parameters in a Contemporary Radical Prostatectomy Series

Abstract Background The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP. Objective To assess the prevalence of a TGG in a contemporary, consecuti...

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Bibliographic Details
Published in:European urology 2009-02, Vol.55 (2), p.394-403
Main Authors: Isbarn, Hendrik, Ahyai, Sascha A, Chun, Felix K.H, Budäus, Lars, Schlomm, Thorsten, Salomon, Georg, Zacharias, Mario, Erbersdobler, Andreas, Köllermann, Jens, Sauter, Guido, Huland, Hartwig, Graefen, Markus, Steuber, Thomas
Format: Article
Language:English
Subjects:
Gleason score
Humans
Lymph Nodes - pathology
Male
Multivariate Analysis
Neoplasm Metastasis - pathology
Odds Ratio
Prevalence
Prostate cancer
Prostatectomy - adverse effects
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - mortality
Prostatic Neoplasms - pathology
Prostatic Neoplasms - surgery
Radical prostatectomy
Recurrence
Regression Analysis
Retrospective Studies
Survival Analysis
Survival Rate
Survivors
Tertiary Gleason grade
Urology
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Summary:Abstract Background The presence of a tertiary Gleason grade (TGG) pattern in radical prostatectomy (RP) specimens has been described as associated with adverse pathology and a higher biochemical recurrence (BCR) rate after RP. Objective To assess the prevalence of a TGG in a contemporary, consecutive, single-centre RP series and its association with adverse pathology. Design, setting, and participants From January to August 2007, 800 eligible patients (no prior neoadjuvant hormonal therapy) underwent RP for clinically localised prostate cancer (pCA) in our institution. The presence of the third most prevalent Gleason pattern was documented, regardless of whether it was better or worse than the two predominant Gleason grades. Measurements The overall prevalence of a TGG was described. Uni- and multivariate logistic regression analyses tested the association between the presence of a TGG
ISSN:0302-2838
1873-7560
DOI:10.1016/j.eururo.2008.08.015