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Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study
Aim: The aim of this study was to estimate the incidence and identify independent risk factors for nosocomial infections in a Danish Neonatal Intensive Care Unit and to compare these findings with international results. Methods: The study was performed prospectively from January 1, 2005 to Decembe...
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| Published in: | Acta Paediatrica 2009-08, Vol.98 (8), p.1294-1299 |
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| Main Authors: | , , , , |
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| cited_by | cdi_FETCH-LOGICAL-c4352-18fd28ca3884aa5ecceb8dc4bd834bd746243f8986e7c1946805914358d8c4373 |
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| cites | cdi_FETCH-LOGICAL-c4352-18fd28ca3884aa5ecceb8dc4bd834bd746243f8986e7c1946805914358d8c4373 |
| container_end_page | 1299 |
| container_issue | 8 |
| container_start_page | 1294 |
| container_title | Acta Paediatrica |
| container_volume | 98 |
| creator | Olsen, Anne L Reinholdt, Jes Jensen, Anders Mørup Andersen, Leif P Jensen, Elsebeth Tvenstrup |
| description | Aim: The aim of this study was to estimate the incidence and identify independent risk factors for nosocomial infections in a Danish Neonatal Intensive Care Unit and to compare these findings with international results.
Methods: The study was performed prospectively from January 1, 2005 to December 31, 2005 in the Neonatal Intensive Care Unit at Rigshospitalet, Copenhagen. Specific criteria for blood stream infection and respiratory tract infection adapted for neonates in our ward were worked out.
Results: Six hundred and eighty‐three patients were included. The overall incidence of nosocomial infection was 8.8/1000 hospital days. Blood stream infection was the most frequent type of infection, with an incidence of 5.1/1000 hospital days. Multivariate analysis showed gestational age and heart disease to be significant independent risk factors for both first time blood stream infection and respiratory tract infection, and central venous catheter and parenteral nutrition risk factors for first time blood stream infection.
Conclusion: This first prospective study of nosocomial infection in a Danish Neonatal Intensive Care Unit found an overall incidence of 8.8/1000 hospital days, which is low or similar compared to other studies. Further Danish multicentre studies are needed, and we suggest that procedures related to central venous catheters should be a future focus area. |
| doi_str_mv | 10.1111/j.1651-2227.2009.01322.x |
| format | article |
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Methods: The study was performed prospectively from January 1, 2005 to December 31, 2005 in the Neonatal Intensive Care Unit at Rigshospitalet, Copenhagen. Specific criteria for blood stream infection and respiratory tract infection adapted for neonates in our ward were worked out.
Results: Six hundred and eighty‐three patients were included. The overall incidence of nosocomial infection was 8.8/1000 hospital days. Blood stream infection was the most frequent type of infection, with an incidence of 5.1/1000 hospital days. Multivariate analysis showed gestational age and heart disease to be significant independent risk factors for both first time blood stream infection and respiratory tract infection, and central venous catheter and parenteral nutrition risk factors for first time blood stream infection.
Conclusion: This first prospective study of nosocomial infection in a Danish Neonatal Intensive Care Unit found an overall incidence of 8.8/1000 hospital days, which is low or similar compared to other studies. Further Danish multicentre studies are needed, and we suggest that procedures related to central venous catheters should be a future focus area.</description><identifier>ISSN: 0803-5253</identifier><identifier>EISSN: 1651-2227</identifier><identifier>DOI: 10.1111/j.1651-2227.2009.01322.x</identifier><identifier>PMID: 19438843</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Bacterial diseases ; Bacterial sepsis ; Biological and medical sciences ; Blood stream infection ; Catheter-Related Infections - epidemiology ; Catheterization, Central Venous - adverse effects ; Central venous catheter ; Cross Infection - epidemiology ; Cross Infection - microbiology ; Denmark - epidemiology ; Female ; General aspects ; Gestational Age ; Heart Diseases - congenital ; Human bacterial diseases ; Human infectious diseases. Experimental studies and models ; Humans ; Incidence ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases - epidemiology ; Infectious diseases ; Intensive Care Units, Neonatal ; Length of Stay ; Male ; Medical sciences ; Multivariate Analysis ; Neonatal Intensive Care Unit ; Nosocomial infection ; Parenteral Nutrition - adverse effects ; Premature neonates ; Proportional Hazards Models ; Prospective Studies ; Respiratory Tract Infections - epidemiology ; Respiratory Tract Infections - microbiology ; Risk Factors ; Sepsis - epidemiology</subject><ispartof>Acta Paediatrica, 2009-08, Vol.98 (8), p.1294-1299</ispartof><rights>2009 The Author(s)/Journal Compilation © 2009 Foundation Acta Pædiatrica</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4352-18fd28ca3884aa5ecceb8dc4bd834bd746243f8986e7c1946805914358d8c4373</citedby><cites>FETCH-LOGICAL-c4352-18fd28ca3884aa5ecceb8dc4bd834bd746243f8986e7c1946805914358d8c4373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21673388$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19438843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olsen, Anne L</creatorcontrib><creatorcontrib>Reinholdt, Jes</creatorcontrib><creatorcontrib>Jensen, Anders Mørup</creatorcontrib><creatorcontrib>Andersen, Leif P</creatorcontrib><creatorcontrib>Jensen, Elsebeth Tvenstrup</creatorcontrib><title>Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study</title><title>Acta Paediatrica</title><addtitle>Acta Paediatr</addtitle><description>Aim: The aim of this study was to estimate the incidence and identify independent risk factors for nosocomial infections in a Danish Neonatal Intensive Care Unit and to compare these findings with international results.
Methods: The study was performed prospectively from January 1, 2005 to December 31, 2005 in the Neonatal Intensive Care Unit at Rigshospitalet, Copenhagen. Specific criteria for blood stream infection and respiratory tract infection adapted for neonates in our ward were worked out.
Results: Six hundred and eighty‐three patients were included. The overall incidence of nosocomial infection was 8.8/1000 hospital days. Blood stream infection was the most frequent type of infection, with an incidence of 5.1/1000 hospital days. Multivariate analysis showed gestational age and heart disease to be significant independent risk factors for both first time blood stream infection and respiratory tract infection, and central venous catheter and parenteral nutrition risk factors for first time blood stream infection.
Conclusion: This first prospective study of nosocomial infection in a Danish Neonatal Intensive Care Unit found an overall incidence of 8.8/1000 hospital days, which is low or similar compared to other studies. Further Danish multicentre studies are needed, and we suggest that procedures related to central venous catheters should be a future focus area.</description><subject>Bacterial diseases</subject><subject>Bacterial sepsis</subject><subject>Biological and medical sciences</subject><subject>Blood stream infection</subject><subject>Catheter-Related Infections - epidemiology</subject><subject>Catheterization, Central Venous - adverse effects</subject><subject>Central venous catheter</subject><subject>Cross Infection - epidemiology</subject><subject>Cross Infection - microbiology</subject><subject>Denmark - epidemiology</subject><subject>Female</subject><subject>General aspects</subject><subject>Gestational Age</subject><subject>Heart Diseases - congenital</subject><subject>Human bacterial diseases</subject><subject>Human infectious diseases. Experimental studies and models</subject><subject>Humans</subject><subject>Incidence</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases - epidemiology</subject><subject>Infectious diseases</subject><subject>Intensive Care Units, Neonatal</subject><subject>Length of Stay</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Multivariate Analysis</subject><subject>Neonatal Intensive Care Unit</subject><subject>Nosocomial infection</subject><subject>Parenteral Nutrition - adverse effects</subject><subject>Premature neonates</subject><subject>Proportional Hazards Models</subject><subject>Prospective Studies</subject><subject>Respiratory Tract Infections - epidemiology</subject><subject>Respiratory Tract Infections - microbiology</subject><subject>Risk Factors</subject><subject>Sepsis - epidemiology</subject><issn>0803-5253</issn><issn>1651-2227</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqNkF1PwjAUhhujUUT_gtmN3m32Yx-diReIikREQyAm3jSl62JxdLgOhX_vmRC8tRftSc7znvP2RcgjOCBwLmcBiSPiU0qTgGKcBpgwSoPVHmrtGvuohTlmfkQjdoSOnZthTFkaxofoiKQh4zxkLTQalq5U5dzIwjM216o2pYXKk96ttMa9e0NdWllDu29rbZ350l5XVtqbWFNfAbaoSrdodNBw9TJbn6CDXBZOn27fNprc3427D_7gudfvdga-CllEfcLzjHIlGyNSRlopPeWZCqcZZ3AlYUxDlvOUxzpRYDjmOEoJSHnGYULC2uhiMxccfC61q8XcOKWLQlpdLp2Ik5ATwiMA-QZUYNVVOheLysxltRYEiyZPMRNNbKKJTTR5it88xQqkZ9sdy-lcZ3_CbYAAnG8B6ZQs8kpaZdyOoyROGJDAXW-4b1Po9b8NiM5Lp6lA72_0xtV6tdPL6gP-yZJIvA57YjR4Gj2O32Jxw34AMF-fLQ</recordid><startdate>200908</startdate><enddate>200908</enddate><creator>Olsen, Anne L</creator><creator>Reinholdt, Jes</creator><creator>Jensen, Anders Mørup</creator><creator>Andersen, Leif P</creator><creator>Jensen, Elsebeth Tvenstrup</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200908</creationdate><title>Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study</title><author>Olsen, Anne L ; Reinholdt, Jes ; Jensen, Anders Mørup ; Andersen, Leif P ; Jensen, Elsebeth Tvenstrup</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4352-18fd28ca3884aa5ecceb8dc4bd834bd746243f8986e7c1946805914358d8c4373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Bacterial diseases</topic><topic>Bacterial sepsis</topic><topic>Biological and medical sciences</topic><topic>Blood stream infection</topic><topic>Catheter-Related Infections - epidemiology</topic><topic>Catheterization, Central Venous - adverse effects</topic><topic>Central venous catheter</topic><topic>Cross Infection - epidemiology</topic><topic>Cross Infection - microbiology</topic><topic>Denmark - epidemiology</topic><topic>Female</topic><topic>General aspects</topic><topic>Gestational Age</topic><topic>Heart Diseases - congenital</topic><topic>Human bacterial diseases</topic><topic>Human infectious diseases. Experimental studies and models</topic><topic>Humans</topic><topic>Incidence</topic><topic>Infant, Newborn</topic><topic>Infant, Premature</topic><topic>Infant, Premature, Diseases - epidemiology</topic><topic>Infectious diseases</topic><topic>Intensive Care Units, Neonatal</topic><topic>Length of Stay</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Multivariate Analysis</topic><topic>Neonatal Intensive Care Unit</topic><topic>Nosocomial infection</topic><topic>Parenteral Nutrition - adverse effects</topic><topic>Premature neonates</topic><topic>Proportional Hazards Models</topic><topic>Prospective Studies</topic><topic>Respiratory Tract Infections - epidemiology</topic><topic>Respiratory Tract Infections - microbiology</topic><topic>Risk Factors</topic><topic>Sepsis - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Olsen, Anne L</creatorcontrib><creatorcontrib>Reinholdt, Jes</creatorcontrib><creatorcontrib>Jensen, Anders Mørup</creatorcontrib><creatorcontrib>Andersen, Leif P</creatorcontrib><creatorcontrib>Jensen, Elsebeth Tvenstrup</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta Paediatrica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olsen, Anne L</au><au>Reinholdt, Jes</au><au>Jensen, Anders Mørup</au><au>Andersen, Leif P</au><au>Jensen, Elsebeth Tvenstrup</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study</atitle><jtitle>Acta Paediatrica</jtitle><addtitle>Acta Paediatr</addtitle><date>2009-08</date><risdate>2009</risdate><volume>98</volume><issue>8</issue><spage>1294</spage><epage>1299</epage><pages>1294-1299</pages><issn>0803-5253</issn><eissn>1651-2227</eissn><abstract>Aim: The aim of this study was to estimate the incidence and identify independent risk factors for nosocomial infections in a Danish Neonatal Intensive Care Unit and to compare these findings with international results.
Methods: The study was performed prospectively from January 1, 2005 to December 31, 2005 in the Neonatal Intensive Care Unit at Rigshospitalet, Copenhagen. Specific criteria for blood stream infection and respiratory tract infection adapted for neonates in our ward were worked out.
Results: Six hundred and eighty‐three patients were included. The overall incidence of nosocomial infection was 8.8/1000 hospital days. Blood stream infection was the most frequent type of infection, with an incidence of 5.1/1000 hospital days. Multivariate analysis showed gestational age and heart disease to be significant independent risk factors for both first time blood stream infection and respiratory tract infection, and central venous catheter and parenteral nutrition risk factors for first time blood stream infection.
Conclusion: This first prospective study of nosocomial infection in a Danish Neonatal Intensive Care Unit found an overall incidence of 8.8/1000 hospital days, which is low or similar compared to other studies. Further Danish multicentre studies are needed, and we suggest that procedures related to central venous catheters should be a future focus area.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>19438843</pmid><doi>10.1111/j.1651-2227.2009.01322.x</doi><tpages>6</tpages></addata></record> |
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| ispartof | Acta Paediatrica, 2009-08, Vol.98 (8), p.1294-1299 |
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| subjects | Bacterial diseases Bacterial sepsis Biological and medical sciences Blood stream infection Catheter-Related Infections - epidemiology Catheterization, Central Venous - adverse effects Central venous catheter Cross Infection - epidemiology Cross Infection - microbiology Denmark - epidemiology Female General aspects Gestational Age Heart Diseases - congenital Human bacterial diseases Human infectious diseases. Experimental studies and models Humans Incidence Infant, Newborn Infant, Premature Infant, Premature, Diseases - epidemiology Infectious diseases Intensive Care Units, Neonatal Length of Stay Male Medical sciences Multivariate Analysis Neonatal Intensive Care Unit Nosocomial infection Parenteral Nutrition - adverse effects Premature neonates Proportional Hazards Models Prospective Studies Respiratory Tract Infections - epidemiology Respiratory Tract Infections - microbiology Risk Factors Sepsis - epidemiology |
| title | Nosocomial infection in a Danish Neonatal Intensive Care Unit: a prospective study |
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