Vascular dysfunction after coarctation repair is related to the age at surgery

Background: Despite repair of aortic coarctation, hypertension is frequent in adults and premature coronary and cerebrovascular disease remain of concern. Persistent impairment of arterial dilation has been suspected to contribute to abnormal blood pressure regulation. We tested the hypothesis that...

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Bibliographic Details
Published in:International journal of cardiology 2005-03, Vol.99 (2), p.295-299
Main Authors: Heger, Maria, Willfort, Andrea, Neunteufl, Thomas, Rosenhek, Raphael, Gabriel, Harald, Wollenek, Gregor, Wimmer, Maria, Maurer, Gerald, Baumgartner, Helmut
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aortic coarctation
Aortic Coarctation - surgery
Biological and medical sciences
Blood and lymphatic vessels
Blood Vessel Prosthesis Implantation - adverse effects
Brachial Artery - diagnostic imaging
Brachial Artery - drug effects
Brachial Artery - physiopathology
Cardiology. Vascular system
Diseases of the aorta
Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous
Endothelium, Vascular - physiopathology
Female
Follow-Up Studies
Humans
Hypertension
Male
Medical sciences
Middle Aged
Nitroglycerin
Peripheral Vascular Diseases - diagnostic imaging
Peripheral Vascular Diseases - etiology
Peripheral Vascular Diseases - physiopathology
Postoperative Complications
Time Factors
Ultrasonography
Ultrasound
Vasodilation - drug effects
Vasodilation - physiology
Vasodilator Agents
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Summary:Background: Despite repair of aortic coarctation, hypertension is frequent in adults and premature coronary and cerebrovascular disease remain of concern. Persistent impairment of arterial dilation has been suspected to contribute to abnormal blood pressure regulation. We tested the hypothesis that arterial reactivity is more likely to be impaired in patients corrected at older age. Methods: We studied changes in brachial artery diameter in response to reactive hyperemia (FMD) and to nitroglycerin (NMD) in 36 patients and 25 controls. Depending on their age at surgery, patients were divided in group A (surgery
ISSN:0167-5273
1874-1754
DOI:10.1016/j.ijcard.2004.02.001