Sonographic Assessment of Facial HIV‐Related Lypoatrophy

OBJECTIVE To investigate the utility of ultrasonography (US) for assessing and grading facial lypoatrophy (FLA) in patients with HIV. DESIGN The social effect of FLA is huge and may reduce antiretroviral therapy adherence. Strategies for the early detection of FLA are crucial, because complete corre...

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Bibliographic Details
Published in:Dermatologic surgery 2009-07, Vol.35 (7), p.1066-1072
Main Authors: PETRONE, ADA, RIZZI, ELISA BUSI, SCHININÀ, VINCENZO, CRISTOFARO, MASSIMO, IVANOVIC, JELENA, BELLAGAMBA, RITA, FRACASSO, LUCA, NICASTRI, EMANUELE, NARCISO, PASQUALE, BIBBOLINO, CORRADO
Format: Article
Language:English
Subjects:
Adult
Antiretroviral Therapy, Highly Active
Biological and medical sciences
Dermatology
Face
Female
HIV-Associated Lipodystrophy Syndrome - diagnostic imaging
HIV-Associated Lipodystrophy Syndrome - drug therapy
Human immunodeficiency virus
Human viral diseases
Humans
Infectious diseases
Male
Medical sciences
Middle Aged
Skin plastic surgery
Subcutaneous Fat - diagnostic imaging
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Ultrasonography
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:OBJECTIVE To investigate the utility of ultrasonography (US) for assessing and grading facial lypoatrophy (FLA) in patients with HIV. DESIGN The social effect of FLA is huge and may reduce antiretroviral therapy adherence. Strategies for the early detection of FLA are crucial, because complete correction of FLA in late stages is unlikely. METHODS Fifty‐two HIV‐positive patients undergoing highly active antiretroviral therapy underwent US with nasogenian transversal scan using a high‐frequency broadband transducer (5–17 MHz) to detect FLA. Intra‐ and interobserver variability were calculated to assess US reproducibility. Concerning FLA grading, patients were categorized in five clinical classes and four US classes. RESULTS Our results regarding inter‐ and intraobserver coefficients of variation permit the validation of US as a reproducible technique (p
ISSN:1076-0512
1524-4725
DOI:10.1111/j.1524-4725.2009.01184.x