Total mandibular reconstruction for massive osteolysis of the mandible (Gorham–Stout syndrome)

Massive osteolysis (Gorham–Stout syndrome) is a rare condition of unknown aetiology that is thought to result from a localised endothelial proliferation of lymphatic vessels resulting in destruction and absorption of bone. The diagnosis of Gorham–Stout syndrome can be made only after first excluding...

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Bibliographic Details
Published in:British journal of oral & maxillofacial surgery 2005-04, Vol.43 (2), p.166-168
Main Authors: Paley, M.D., Lloyd, C.J., Penfold, C.N.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Bone Transplantation - methods
Dentistry
Diseases of the osteoarticular system
Female
Fibula - transplantation
Gorham–Stout syndrome
Humans
Joint Prosthesis
Mandible
Mandible - surgery
Mandibular Diseases - surgery
Massive osteolysis
Medical sciences
Middle Aged
Miscellaneous. Osteoarticular involvement in other diseases
Oral Surgical Procedures
Osteolysis, Essential - surgery
Otorhinolaryngology. Stomatology
Reconstruction
Recurrence
Reoperation
Syndrome
Temporomandibular Joint - surgery
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Summary:Massive osteolysis (Gorham–Stout syndrome) is a rare condition of unknown aetiology that is thought to result from a localised endothelial proliferation of lymphatic vessels resulting in destruction and absorption of bone. The diagnosis of Gorham–Stout syndrome can be made only after first excluding osteolysis from infection, inflammation, endocrine disease, and cancer. The syndrome is rarely seen in the facial skeleton and has a variable prognosis. Many treatments have been advocated but only surgery and radiotherapy have had some success. We present a case of massive osteolysis of the entire mandible, which was reconstructed with a free vascularised fibular graft and bilateral prosthetic replacements of the temporomandibular (TMJ) joints. Four years later the fibular graft had been absorbed requiring further reconstruction with another fibula graft.
ISSN:0266-4356
1532-1940
DOI:10.1016/j.bjoms.2004.09.008