Transmigration through venular walls: a key regulator of leukocyte phenotype and function

Leukocyte transmigration is a key event in host defense. As well as delivering leukocytes to sites of inflammation, this response also has an important role in immunity by regulating the responsiveness and behavior of leukocytes in the extravascular tissue. Recent evidence suggests that these events...

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Bibliographic Details
Published in:Trends in immunology 2005-03, Vol.26 (3), p.157-165
Main Authors: Nourshargh, Sussan, Marelli-Berg, Federica M.
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Animal diseases
Animals
Apoptosis
Cell adhesion & migration
Cell Membrane - physiology
Cell Movement - immunology
Chemokines
Endothelium
Endothelium, Vascular - immunology
Endothelium, Vascular - physiology
Genotype & phenotype
Humans
Immune system
Immunophenotyping
Leukocytes
Leukocytes - immunology
Leukocytes - physiology
Lymphocytes
Models, Biological
Motility
Rodents
Venules - immunology
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Summary:Leukocyte transmigration is a key event in host defense. As well as delivering leukocytes to sites of inflammation, this response also has an important role in immunity by regulating the responsiveness and behavior of leukocytes in the extravascular tissue. Recent evidence suggests that these events are associated with phenotypic and functional changes in migrating leukocytes mediated by signaling and transcriptional events triggered by the molecular interactions involved in leukocyte transendothelial cell migration. Transfer of membrane proteins from endothelial cells to migrating leukocytes and interaction of leukocytes with components of the perivascular basement membrane might also contribute to this effect. This Review will discuss the characteristics, potential mechanisms and the relevance of transmigration-induced change in leukocyte phenotype and responsiveness both within physiological and pathological scenarios.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2005.01.006