Reference ranges for serial measurements of umbilical artery Doppler indices in the second half of pregnancy

The purpose of this study was to construct new reference ranges for serial measurements of commonly used umbilical artery Doppler indices (pulsatility index, resistance index, and systolic:diastolic ratio). This was a prospective longitudinal study of the umbilical artery Doppler indices that were o...

Full description

Saved in:
Bibliographic Details
Published in:American journal of obstetrics and gynecology 2005-03, Vol.192 (3), p.937-944
Main Authors: Acharya, Ganesh, Wilsgaard, Tom, Berntsen, Gro K. Rosvold, Maltau, Jan Martin, Kiserud, Torvid
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Birth Weight
Doppler index
Female
Fetus
Gynecology. Andrology. Obstetrics
Humans
Infant, Newborn
Longitudinal Studies
Male
Medical sciences
Observer Variation
Placenta
Pregnancy
Pregnancy Trimester, Second
Pregnancy Trimester, Third
Prospective Studies
Reference Values
Sex Factors
Ultrasonography, Doppler
Umbilical Arteries - anatomy & histology
Umbilical Arteries - diagnostic imaging
Umbilical artery
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The purpose of this study was to construct new reference ranges for serial measurements of commonly used umbilical artery Doppler indices (pulsatility index, resistance index, and systolic:diastolic ratio). This was a prospective longitudinal study of the umbilical artery Doppler indices that were obtained serially at the free-loop of umbilical cord at 4-week intervals at 19 to 42 weeks of gestation in 130 low-risk singleton pregnancies. A total of 513 observations were used to construct the reference ranges with the use of multilevel modeling. Longitudinally established percentiles of Doppler indices from the present study show a continuous reduction throughout the second half of pregnancy without any plateau or increase near term, as reported previously. There was a significant negative association between Doppler indices and placental weight and neonatal birth weight, but not with gender. The intraobserver coefficients of variation for the umbilical artery pulsatility index, resistance index, and systolic:diastolic ratio were 10.5%, 6.8 %, and 13.0 %, respectively. New reference ranges for umbilical artery Doppler indices that are based on longitudinal observations appear to be slightly different from cross-sectional studies and are more appropriate for serial evaluation of fetal hemodynamics.
ISSN:0002-9378
1097-6868
DOI:10.1016/j.ajog.2004.09.019