The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes

Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all....

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Bibliographic Details
Published in:Diabetologia 2005-02, Vol.48 (2), p.309-316
Main Authors: PÖYKKÖ, S. M, UKKOLA, O, KAUMA, H, KELLOKOSKI, E, HÖRKKÖ, S, KESÄNIEMI, Y. A
Format: Article
Language:English
Subjects:
Adult
Arteriosclerosis - epidemiology
Biological and medical sciences
Cohort Studies
Diabetes Mellitus, Type 2 - blood
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Female
Finland - epidemiology
Ghrelin
Humans
Insulin Resistance - physiology
Insulin-Like Growth Factor I - metabolism
Male
Medical sciences
Metabolic diseases
Middle Aged
Obesity
Obesity - blood
Peptide Hormones - blood
Regression Analysis
Reproducibility of Results
Risk Factors
Sex Characteristics
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Summary:Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association. We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI. IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (beta=-0.32, p
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-004-1635-9