Cytomegalovirus retinitis in a patient with non-Hodgkin's lymphoma: a diagnostic dilemma

• Published in: European journal of ophthalmology 2005-01, Vol.15 (1), p.153-157
• Main Authors: Chawla, R, Venkatesh, P, Garg, S P, Mandal, S, Tewari, H K
• Format: Article
• Language: English
• Subjects: Adult; CD4 Lymphocyte Count; Cytomegalovirus - genetics; Cytomegalovirus - isolation & purification; Cytomegalovirus Retinitis - diagnosis; Cytomegalovirus Retinitis - drug therapy; Cytomegalovirus Retinitis - virology; Diagnosis, Differential; DNA, Viral - analysis; Humans; Lymphoma, Non-Hodgkin - diagnosis; Lymphoma, Non-Hodgkin - drug therapy; Lymphoma, Non-Hodgkin - virology; Male; Polymerase Chain Reaction; Vitreous Body - virology
• ISSN: 1120-6721; 1724-6016
• DOI: 10.1177/112067210501500127

Patients with lymphoma can rarely develop cytomegalovirus (CMV) retinitis. Clinically it is difficult to distinguish from intraocular lymphoma. Also, in such cases the CD4+ count may be high. The authors report a rare case of bilateral CMV retinitis in a patient with non-Hodgkin's lymphoma with high CD4+ counts. Observational case report with review of literature. CMV retinitis was clinically suspected due to the presence of large areas of retinal necrosis and hemorrhages in one eye and a demarcation line with white mottled retina in the other eye. Other differential diagnoses considered were intraocular lymphomatous infiltration and acute retinal necrosis due to herpes group of viruses. The diagnosis of CMV retinitis was confirmed by polymerase chain reaction performed on vitreous sample. CMV retinitis can develop in cases of lymphoma despite high CD4+ counts. An early diagnosis can be established by performing PCR on vitreous biopsy.