Genetic association between matrix metalloproteinase MMP-9 and MMP-3 polymorphisms and Japanese sporadic Alzheimer's disease

Recent studies suggested that matrix metalloproteinases (MMPs) might play an important role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and MMP–3 are reported to degrade amyloid β and have several functional polymorphisms associated with other common diseases. Four common polymorp...

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Bibliographic Details
Published in:Neurobiology of aging 2005-07, Vol.26 (7), p.1011-1014
Main Authors: Shibata, Nobuto, Ohnuma, Tohru, Higashi, Shinji, Usui, Chie, Ohkubo, Taku, Kitajima, Akiyoshi, Ueki, Akira, Nagao, Masatsugu, Arai, Heii
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alzheimer Disease - genetics
Alzheimer's disease
Biological and medical sciences
Confidence Intervals
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Female
Gene Frequency - physiology
Genetic polymorphism
Genetic Predisposition to Disease
Humans
Japan - epidemiology
Linkage Disequilibrium
Male
Matrix Metalloproteinase 3 - genetics
Matrix Metalloproteinase 9 - genetics
Matrix metalloproteinases
Medical sciences
Middle Aged
Neurology
Odds Ratio
Polymorphism, Genetic
Promoter Regions, Genetic
Reverse Transcriptase Polymerase Chain Reaction - methods
RNA, Messenger - biosynthesis
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Summary:Recent studies suggested that matrix metalloproteinases (MMPs) might play an important role in the pathophysiology of Alzheimer's disease (AD). MMP-9 and MMP–3 are reported to degrade amyloid β and have several functional polymorphisms associated with other common diseases. Four common polymorphisms in each of MMP-9 and MMP–3 were examined in AD cases and normal control individuals. Common polymorphisms of MMP-9, rs3918248, rs2664538, rs2250889 and rs2274756 showed no association with risk for AD. We observed strong linkage disequilibrium (LD) between rs2664538 and rs2250889 in our Japanese samples. The polymorphisms of MMP-3; 5A/6A insertion polymorphism in the promoter, rs3025079, rs520540 and rs679620 also did not influence risk for AD. LD of the 5A/6A polymorphism with rs679620 was relatively strong. These results suggest that the common polymorphisms of MMP-9 and MMP–3 investigated here are not associated with AD.
ISSN:0197-4580
1558-1497
DOI:10.1016/j.neurobiolaging.2004.09.004