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First-trimester Screening: An Overview

An improvement in prenatal screening for chromosomal defects has been achieved by combining sonography and biochemical markers. Analyzing markers taken from maternal blood such as pregnancy-associated plasma protein A and free β-human chorionic gonadotropin in combination with the ultrasound marker...

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Bibliographic Details
Published in:The journal of histochemistry and cytochemistry 2005-03, Vol.53 (3), p.281-283
Main Authors: Eiben, Bernd, Glaubitz, Ralf
Format: Article
Language:English
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Summary:An improvement in prenatal screening for chromosomal defects has been achieved by combining sonography and biochemical markers. Analyzing markers taken from maternal blood such as pregnancy-associated plasma protein A and free β-human chorionic gonadotropin in combination with the ultrasound marker nuchal translucency provides detection rates of 90% for the most important chromosomal anomalies. In addition, nuchal translucency is a marker for severe heart defects. This report discusses the potential of new markers such as the nasal bone.
ISSN:0022-1554
1551-5044
DOI:10.1369/jhc.4B6420.2005