The t(12:21) is underrepresented in childhood B-lineage acute lymphoblastic leukemia in Kerala, Southern India

t(12;21) (TEL/AML1) is the most common genetic event in childhood B-cell acute lymphoblastic leukemia (B-ALL) in Western countries. Samples from 42 children with ALL in Kerala were tested by reverse transcription polymerase chain reaction for TEL/AML1, t(1;19) and t(4;11). Only 2 out of 42 (4.8%) ca...

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Bibliographic Details
Published in:Haematologica (Roma) 2005-03, Vol.90 (3), p.414-416
Main Authors: Hill, A, Short, MA, Varghese, C, Kusumakumary, P, Kumari, P, Morgan, GJ
Format: Article
Language:English
Subjects:
Child
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 21
Humans
Incidence
India - epidemiology
Leukemia, B-Cell
Molecular Epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - epidemiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Translocation, Genetic
Online Access:Get full text
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Summary:t(12;21) (TEL/AML1) is the most common genetic event in childhood B-cell acute lymphoblastic leukemia (B-ALL) in Western countries. Samples from 42 children with ALL in Kerala were tested by reverse transcription polymerase chain reaction for TEL/AML1, t(1;19) and t(4;11). Only 2 out of 42 (4.8%) cases were positive for the TEL/AML1, and t(1;19) and t(4;11) were not detected. We conclude that the incidence of TEL/AML1 is lower in the Indian population.
ISSN:0390-6078
1592-8721