Decreased E-cadherin expression correlates with higher stage of Wilms' tumors

The aim of this study was to examine the association between E-cadherin expression and markers of Wilms' tumor aggression, including metastasis and recurrence. Forty Wilms' tumor samples from the National Wilms' Tumor Study Group underwent immunohistochemical staining for E-cadherin....

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Bibliographic Details
Published in:Journal of pediatric surgery 2005-02, Vol.40 (2), p.341-348
Main Authors: Safford, Shawn D., Freemerman, Alex J., Langdon, Scott, Bentley, Rex, Goyeau, Dominique, Grundy, Paul E., Skinner, Michael A.
Format: Article
Language:English
Subjects:
Cadherins - analysis
Cadherins - biosynthesis
Cadherins - genetics
Cell Adhesion
Child
Chromatography, High Pressure Liquid - methods
Chromosomes, Human, Pair 16
DNA Mutational Analysis
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Kidney Neoplasms - genetics
Kidney Neoplasms - metabolism
Kidney Neoplasms - pathology
Loss of Heterozygosity
Neoplasm Metastasis - genetics
Neoplasm Recurrence, Local - genetics
Neoplasm Staging
Polymorphism, Single Nucleotide
RNA, Messenger - analysis
Wilms Tumor - genetics
Wilms Tumor - metabolism
Wilms Tumor - pathology
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Summary:The aim of this study was to examine the association between E-cadherin expression and markers of Wilms' tumor aggression, including metastasis and recurrence. Forty Wilms' tumor samples from the National Wilms' Tumor Study Group underwent immunohistochemical staining for E-cadherin. Tumor stage at diagnosis, recurrence, and loss of heterozygosity at 16q status was known for each of the tumor samples. E-Cadherin cell staining was defined as high (>33%) or low (
ISSN:0022-3468
1531-5037
DOI:10.1016/j.jpedsurg.2004.10.030