Varied patterns of DNA methylation change between different satellite regions in bovine preimplantation development

Global reduction of DNA methylation, a part of genome reprogramming processes, occurs in a gradual manner until before implantation and is recognized as a conserved process in mammals. Here, we reported that in bovine, satellite regions exhibited varied patterns of methylation changes when one‐cell...

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Published in:Molecular reproduction and development 2005-05, Vol.71 (1), p.29-35
Main Authors: Kang, Yong-Kook, Lee, Hyo-Jong, Shim, Jung-Jae, Yeo, Seungeun, Kim, Seok-Ho, Koo, Deog-Bon, Lee, Kyung-Kwang, Beyhan, Zeki, First, Neal L., Han, Yong-Mahn
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Biological and medical sciences
Blastocyst - metabolism
bovine
Cattle
demethylation
DNA Methylation
DNA, Satellite - genetics
DNA, Satellite - metabolism
Early stages. Segmentation. Gastrulation. Neurulation
Embryology: invertebrates and vertebrates. Teratology
Embryonic Development - genetics
Fertilization in Vitro
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation, Developmental
Molecular Sequence Data
preimplantation embryo
satellite sequences
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Summary:Global reduction of DNA methylation, a part of genome reprogramming processes, occurs in a gradual manner until before implantation and is recognized as a conserved process in mammals. Here, we reported that in bovine, satellite regions exhibited varied patterns of methylation changes when one‐cell egg advanced to the blastocyst; a maintenance methylation was observed in satellite I sequences, a decrease in alpha satellites, and an increase in satellite II regions. Cloned embryos exhibited similar changes for DNA methylation in the satellite I and alpha. We also observed that the satellite I and α sequences were methylated more in inner cell mass region of the blastocyst whereas the satellite II showed selective demethylation in this region. Together, these findings point that individual satellite sequences carry their own methylation patterns under the pressure of global demethylation, suggesting that local methylation control system acts on the satellite regions in early bovine embryos. Mol. Reprod. Dev. 71: 29–35, 2005. © 2005 Wiley‐Liss, Inc.
ISSN:1040-452X
1098-2795
DOI:10.1002/mrd.20249